Relationship of glycemic variability and diabetes risk factors in pregnant women

Česká verzia

Authors: Martina Gáborová ¹; Viera Doničová ²
Authors place of work: Ústav lekárskej fyziológie LF UPJŠ v Košiciach ¹; Interná a diabetologická ambulancia, Košice ²
Published in the journal: Diab Obez 2022; 22(43): 9-15
Category: Original paper

Summary

The aim of this study was to compare glycemic variability (GV) in pregnant women with and without gestational diabetes mellitus and also to assess the relationship of glycemic variability to risk factors for diabetes. Pregnant women enrolled in the study were divided into a group of women with gestational diabetes mellitus (GDM) and without gestational diabetes mellitus, i.e., the control group (CG), based on the results of the oral glucose tolerance test (oGTT, 2018 Slovak Diabetes Society criteria). After collection of anamnestic, biometric and biochemical parameters, the pregnant women were set up for double-blind 7-day glucose measurement using continuous glucose monitoring (iPro2®Professional CGM).Glycemic variability as expressed by glycemic area under the concentration curve (Total AUC) was statistically significantly higher in women with GDM compared to KS (p = 0,006). The other parameters of glycemic variability [standard deviation, coefficient of variability, J-index, percentage of time spent above the target value of 7.8 mmol/l (%TAR), percentage of time in the target range of 3.5–7.8 mmol/l (%TIR), percentage of time below the target value of 3.5 mmol/l (%TBR)] were not statistically significantly different in the follow-up groups. Diabetes risk factors (positive family history of diabetes, preconception BMI, higher weight gain and higher age at conception) were significantly correlated with glycemic control parameters. In our study, we found that all pregnant women with diabetes risk factors present tended to have higher glycemic variability associated with various feto-uterine complications.

Keywords:

continuous glucose monitoring – gravidity – glycemic compensation – glycemic variability – GDM risk factors

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