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Metformin in the treatment of type 2 diabetes mellitus and its current position


Authors: Zbynek Schroner
Authors place of work: Lekárska fakulta, Univerzita Pavla Jozefa Šafárika v Košiciach
Published in the journal: Diab Obez 2024; 24(47): 21-23
Category: Reviews

Summary

Over the past two decades, the cost of treating type 2 diabetes mellitus (T2DM) has increased dramatically, and a greater financial burden is being passed on to T2DM patients and their families [1]. Medication co-payments can be a major source of stress for people with T2DM and contribute to poorer medication use [2]; in many cases, cost reduction strategies can improve treatment as well as patient behavior [3]. Metformin is still recommended as a first-line antidiabetic treatment for patients with T2DM because of its relatively high efficacy to modify glyc­aemia and HbA1c and other benefits.

Keywords:

HbA1c – glycemia – type 2 diabetes mellitus (T2DM)


Zdroje

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[U.S. Food and Drug Administration]. FDA drug safety communication: FDA revises warnings regarding use of the diabetes medicine metformin in certain patients with reduced kidney function. 2017. Dostupné z WWW: <https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-revises-warnings-regarding-use-diabetes-medicine-metformin-certain>.

Out M, Kooy A, Lehert P et al. Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3 year trial. J Diabetes Complications 2018; 32(2): 171–178. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jdiacomp.2017.11.001>.

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Cahn A, Cefalu WT. Clinical considerations for use of initial combination therapy in type 2 diabetes. Diabetes Care 2016; 39(Suppl 2): S137–S145. Dostupné z DOI: <http://dx.doi.org/10.2337/dcS15–3007>.

Štítky
Diabetology Obesitology

Článok vyšiel v časopise

Diabetes and obesity

Číslo 47

2024 Číslo 47
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