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Dynamics of the Incidence of Creutzfeldt-Jakob Disease in Slovakia in 1975-2008


Authors: E. Mitrová
Authors place of work: Národné referenčné centrum prionových chorôb, Vedeckovýskumná základňa Slovenskej zdravotníckej univerzity v Bratislave
Published in the journal: Epidemiol. Mikrobiol. Imunol. 58, 2009, č. 4, s. 173-178

Summary

The paper reports on Creutzfeldt-Jakob disease (CJD) occurence in Slovakia in years 1975 - 2008. Changes in the incidence of this most important human prion disease, occurrence of individual forms of the classical CJD variant and the unique, unusually high proportion of genetic CJD are documented. Endo- and exogenous risk factors are analyzed, gaps in the prevention of iatrogenic infection are pointed out and the profylaxis of genetic CJD is discussed.

Key words:
Creutzfeldt-Jakob disease, incidence, risk factors.


Zdroje

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3. Collins, S., Law, M., Fletcher, A. at al. Surgical treatment and risk of sporadic CJD: a case control study. Lancet, 1999, 353, 693-697.

4. Kovacs, G., Puopulo, A., Ladogana, A. et al. Genetic prion disease: the EUROCJD experience. Hum Gen, 2005, 113, 439-450.

5. Mitrová, E. Some new aspects of CJD epidemiology in Slovakia. Europ J Epidem, 1991, 7, 439-448.

6. Mitrová, E. and Belay, G. Creutzfeldt-Jakob disease with E200K mutation in Slovakia: characterization and development. Acta Virol, 2002, 46, 31-39.

7. Mitrová, E., Mayer,V., Jovankovičová,V. et al. CJD risk and PRNP codon 129 polymorphism: necessity to revalue current data. Europ J Neurol, 2005, 12, 1-4.

8. Swan, K., Baker, A., Brown, L. vCJD patient abnormal prion protein found in a patient with hemophilia at post mortem. www.nationalprionclinic.uk, 17 February 2009.

9. Will, R.G, Ironside, J., Zeidler, M. A new variant of Creutzfeldt-Jakob disease in UK. Lancet,1996, 347, 197-199.

10. WHO manual for strenghtening diagnosis and surveillance of CJD. Geneva, 1998,1-75.

Štítky
Hygiene and epidemiology Medical virology Clinical microbiology

Článok vyšiel v časopise

Epidemiology, Microbiology, Immunology

Číslo 4

2009 Číslo 4

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