Campylobacteriosis at the Department of Infectious Diseases of the University Hospital Brno in 2011–2013: a retrospective study
Authors:
P. Polák 1,2; M. Vrba 3; Z. Bortlíček 4; J. Juránková 3,5; M. Freibergerová 1; P. Husa 1,2; J. Kamelander 6; M. Dastych 1,7
Authors place of work:
Lékařská fakulta Masarykovy univerzity Brno
1; Klinika infekčních chorob, Fakultní nemocnice Brno
2; Oddělení klinické mikrobiologie, Fakultní nemocnice Brno
3; Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity Brno
4; Katedra laboratorních metod, Lékařská fakulta Masarykovy univerzity Brno
5; Oddělení klinické hematologie, Fakultní nemocnice Brno
6; Oddělení klinické biochemie, Fakultní nemocnice Brno
7
Published in the journal:
Epidemiol. Mikrobiol. Imunol. 64, 2015, č. 3, s. 153-159
Category:
Original Papers
Summary
Objective:
To provide basic clinical, laboratory, and microbiological characteristics of adult patients with campylobacteriosis admitted to the Department of Infectious Diseases University Hospital Brno (UHB), in 2011–2013.
Materials and methods:
A retrospective analysis of clinical and laboratory parameters of 160 patients hospitalized with campylobacteriosis at the Department of Infectious Diseases, UHB from 1 January 2011 to 31 December 2013.
Results:
There was no lethality or bacteremia reported in the study group of 160 adult patients (n = 160) with campylobacteriosis. A more severe form of the disease with signs of systemic inflammatory response syndrome (SIRS) occurred in 24 patients, i.e. 15% of the study population. Transient mild to moderate leukocytopenia and thrombocytopenia were seen in 16 (10.0%) and 24 patients (15.0%), respectively, and seven patients (4.4%) had bicytopenia. The following factors correlated statistically significantly with the intestinal form of the disease and SIRS: age under 70 years (p = 0.037), absence of arterial hypertension (p = 0.044), immunosuppressive treatment (p = 0.008), leukocyte count in the peripheral blood over 12.0 × 109/l (p = 0.023), and body temperature over 38.0 °C (p < 0.001). Antibiotic treatment was used in 96.3% of patients with the intestinal form and in 100.0% of patients with SIRS. The average duration of antibiotic treatment was 8.8 and 9.3 days, respectively. Postantibiotic colitis due to Clostridium difficile occurred in seven patients (4.4%). There were no organ or autoimmune complications observed.
Conclusions:
Campylobacteriosis with SIRS occurs preferentially in persons under 70 years of age. Empirical antibiotic treatment is used too frequently without being adequately deescalated.
Keywords:
campylobacteriosis – invasive disease – antibiotic resistance
Zdroje
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Štítky
Hygiene and epidemiology Medical virology Clinical microbiologyČlánok vyšiel v časopise
Epidemiology, Microbiology, Immunology
2015 Číslo 3
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