Norovirus infections in the Czech Republic in 2008–2020
Authors:
P. Pazdiora 1
; H. Jelínková 1; N. Bartoníková 2; E. Gartnerová 3; J. Kudová 4; I. Vidličková 5; M. Vrba 6; P. Lenz 7; H. Tomášková 8
Authors place of work:
Ústav epidemiologie Lékařské fakulty v Plzni, UK
1; Oddělení lékařské mikrobiologie, Nemocnice Tomáše Bati ve Zlíně
2; Oddělení laboratorní medicíny, Nemocnice AGEL Prostějov, AGEL Středomoravská nemocniční a. s.
3; Oddělení virologie, sérologie a parazitologie, Ústav mikrobiologie LF a FN v Plzni
4; Oddělení virologie, Zdravotní ústav se sídlem v Ostravě
5; Oddělení klinické mikrobiologie, FN Brno-Bohunice
6; Národní referenční centrum pro analýzu epidemiologických dat, Státní zdravotní ústav v Praze
7; Ústav epidemiologie a ochrany veřejného zdraví, Lékařská fakulta, Ostravská univerzita
8
Published in the journal:
Epidemiol. Mikrobiol. Imunol. 71, 2022, č. 2, s. 78-85
Category:
Original Papers
Summary
Introduction: Noroviruses, together with rotaviruses, are the most common cause of viral gastroenteritis in the Czech Republic (CR). The aim of this study was to analyse data on the incidence of norovirus gastroenteritis in the CR and thus to add to the body of knowledge about its significance.
Material and Methods: A descriptive analysis was performed of the basic characteristics of norovirus gastroenteritis reported under ICD-10 code A08.1 to the Epidat or ISIN electronic infectious diseases information system between 2008 and 2020. On the basis of reports from five microbiological laboratories, weekly data on confirmed cases of norovirus infection from 2010–2020 were analysed. Databases of microbiology laboratories from across the Czech Republic were searched to determine the number of the laboratories where norovirus infections were diagnosed and the methods used for this purpose in 2008–2020.
Results: From 2008 to 2020, 33,575 cases of norovirus gastroenteritis were reported to the infectious diseases information systems, which equates to an annual incidence of 24.5/100,000 population, varying between years from 8.2 to 77.1/100,000. Men accounted for 40.2% of cases with an incidence of 20.1/100,000 compared to 28.8/100,000 recorded in women. Of the total of reported cases, 14,282 patients (42.5%) required hospital admission. Over the whole study period, 7,431 cases of norovirus gastroenteritis were recorded in children under 5 years of age. This age category accounted for 13.7–38.9% of the annual totals of reported cases. The incidences were 101.8/100,000 in children under 5 years of age, 40.1/100,000 in 5-14-year-olds, 12.7/100,000 in 15-64-year-olds, and 38.2/100,000 in the age group 65 years and over. Twenty-four deaths (case fatality rate of 0.07%) were reported as associated with norovirus gastroenteritis at the ages 42-94. In the age categories 15-64 years and 65 years and over, the case fatality rates were 0.02% and 0.24%, respectively.
Over the study period, 274 epidemics occurred, during which 16,893 (50.3%) of the total of 33,575 cases were reported. In the epidemic outbreaks, 1,694 (10.0%) patients required hospital admission. The largest outbreak with 5,248 reported cases in 2015 was associated with contamination of the Prague water supply system.
Norovirus infections were laboratory diagnosed year-round, peaking in the autumn and winter months. They are currently diagnosed by 81 laboratories in the Czech Republic, 90.1% of which use immunochromatographic tests.
Conclusion: The study confirmed the highest incidence of norovirus gastroenteritis among children under 5 years of age and the highest case fatality rate in the age group 65 years and over. Over half of the reported cases were outbreak associated. Most laboratories use immunochromatographic tests. The use of more sensitive laboratory methods would improve diagnosis.
Keywords:
Norovirus – Gastroenteritis – case fatality rate – epidemic – seasonal occurrence – infection in children
Zdroje
1. Ahmed SM, Hall AJ, Robinson AE, et al. Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis. Lancet Infect Dis., 2014;14(8):725–730.
2. Brůčková M, Rýc M, Zelenková L, et al. Norwalk-like viry jako pravdĕpodobné etiologické agens epidemie nebakteriální gastroenteritidy [Norwalk-like viruses as probable etiological agents in the epidemic of non-bacterial gastroenteritis (author‘ s transl)]. Epidemiol Mikrobiol Imunol., 1982;31(2):67–72.
3. Burke RM, Mattison C, Marsh Z, et al. Norovirus and Other Viral Causes of Medically Attended Acute Gastroenteritis Across the Age Spectrum: Results from the MAAGE Study in the United States. Clin Infect Dis., 2021:ciab033.
4. Desselberger U, Goodfellow I. Noroviruses: a global cause of acute gastroenteritis. Lancet Infect Dis., 2014;14(8):664–665.
5. Epidemiologický informačný systém EPIS, ÚVZ SR: www.epis.sk.
6. Farahmand M, Moghoofei M, Dorost A, et al Global prevalence and genotype distribution of norovirus infection in children with gastroenteritis: A meta-analysis on 6 years of research from 2015 to 2020. Rev Med Virol., 2022;32(1):e2237.
7. Hall AJ, Rosenthal M, Gregoricus N, et al. Incidence of acute gastroenteritis and role of norovirus, Georgia, USA, 2004–2005. Emerg Infect Dis., 2011;17(8):1381–1388.
8. Hall AJ, Curns AT, McDonald LC, et al. The roles of Clostridium difficile and norovirus among gastroenteritis-associated deaths in the United States, 1999–2007. Clin Infect Dis., 2012;55(2):216– 223.
9. Hassan F, Kanwar N, Harrison CJ, et al. Viral Etiology of Acute Gastroenteritis in <2-Year-Old US Children in the Post-Rotavirus Vaccine Era. J Pediatric Infect Dis Soc., 2019;8(5):414–421.
10. Chhabra P, de Graaf M, Parra GI, et al. Updated classification of norovirus genogroups and genotypes. J Gen Virol., 2019;100(10):1393–1406.
11. Chhabra P, Graaf M, Parra GI, et al. Corrigendum: Updated classification of norovirus genogroups and genotypes. J Gen Virol., 2020;101(8):893.
12. Kele B, Abrok MP, Deak J. Sporadic norovirus infections among hospitalized and non-hospitalized 0-3-year-old infants. Scand J Infect Dis., 2009;41(1):67–69.
13. Kele B, Lengyel G, Deak J. Comparison of an ELISA and two reverse transcription polymerase chain reaction methods for norovirus detection. Diagn Microbiol Infect Dis., 2011;70(4):475–478.
14. Korcinska MR, Dalsgaard Bjerre K, Dam Rasmussen L et al. Detection of norovirus infections in Denmark, 2011–2018. Epidemiol Infect., 2020;148:e52.
15. Kowalzik F, Riera-Montes M, Verstraeten T, et al. The burden of norovirus disease in children in the European Union. Pediatr Infect Dis J., 2015;34(3):229–234.
16. Krsek D, Kodym P. Úloha transmisní elektronové mikroskopie v objasnění epidemie gastroenteritidy z kontaminované pitné vody na Praze 6. Zprávy CEM (SZÚ, Praha), 2015; 24(10):337–339.
17. Lindsay L, Wolter J, De Coster I, et al. A decade of norovirus disease risk among older adults in upper-middle and high income countries: a systematic review. BMC Infect Dis., 2015;15:425.
18. Lopman BA, Steele D, Kirkwood CD, et al. The Vast and Varied Global Burden of Norovirus: Prospects for Prevention and Control. PLoS Med., 2016;13(4):e1001999.
19. Muhsen K, Kassem E, Rubenstein U, et al. No evidence of an increase in the incidence of norovirus gastroenteritis hospitalizations in young children after the introduction of universal rotavirus immunization in Israel. Hum Vaccin Immunother., 2019;15(6):1284–1293.
20. Patel MM, Widdowson MA, Glass RI, et al. Systematic literature review of role of noroviruses in sporadic gastroenteritis. Emerg Infect Dis., 2008;14(8):1224–1231.
21. Pazdiora P, Vašíčková P, Krzyžánková M. Genotypy norovirů u pacientů Fakultní nemocnice v Plzni, Česká republika, 2017–2020. Epidemiol Mikrobiol Imunol., 2021;70 (4): 233–240.
22. Phillips G, Tam CC, Conti S, et al. Community incidence of norovirus- associated infectious intestinal disease in England: improved estimates using viral load for norovirus diagnosis. Am J Epidemiol., 2010;171(9):1014–1022.
23. Puustinen L, Blazevic V, Salminen M, et al. Noroviruses as a major cause of acute gastroenteritis in children in Finland, 2009–2010. Scand J Infect Dis., 2011;43(10):804–808.
24. Infektionsepidemiologisches Jahrbuch meldepflichtiger Krankheiten fur 2008. Robert Koch-Institut, Berlin, ISBN 978-3-89606-111- 9. Dostupné na www: https://www.rki.de/DE/Content/Infekt/ Jahrbuch/Jahrbuch_2008.pdf?__blob=publicationFile.
25. Infektionsepidemiologisches Jahrbuch meldepflichtiger Krankheiten fur 2019. Robert Koch-Institut, Berlin, ISBN 978-3-89606-306- 9. Dostupné na www: https://www.rki.de/DE/Content/Infekt/ Jahrbuch/Jahrbuch_2019.pdf?__blob=publicationFile.
26. Sadkowska-Todys M, Zieliński A, Czarkowski MP. Infectious diseases in Poland in 2016. Przegl Epidemiol., 2018;72(2):129–141.
27. Scallan E, Hoekstra RM, Angulo FJ, et al. Foodborne illness acquired in the United States-major pathogens. Emerg Infect Dis., 2011;17(1):7–15.
28. Špačková M, Gašpárek M. Výskyt nejběžnějších infekčních onemocnění přenášených potravinami a vodou v České republice v r. 2017, přednáška duben 2018. Dostupné na www: http://www.szu.cz/tema/prevence/vyskyt-nejbeznejsich-infekcnich- onemocneni-prenasenych.
29. Tam CC, Rodrigues LC, Viviani L, et al. IID2 Study Executive Committee. Longitudinal study of infectious intestinal disease in the UK (IID2 study): incidence in the community and presenting to general practice. Gut, 2012;61(1):69–77.
30. Thomas MK, Murray R, Flockhart L, et al. Estimates of the burden of foodborne illness in Canada for 30 specified pathogens and unspecified agents, circa 2006. Foodborne Pathog Dis., 2013;10(7):639–648.
31. Trivedi TK, DeSalvo T, Lee L, et al. Hospitalizations and mortality associated with norovirus outbreaks in nursing homes, 2009– 2010. JAMA, 2012;308(16):1668–1675.
32. Truksová B, Kithierova E, Jech J, et al Epidemie akutní infekční nebakteriální gastroenteritidy. Cas Lek Cesk, 1976;115(12):351– 354.
34. van Beek J, de Graaf M, Al-Hello H, et al. NoroNet. Molecular surveillance of norovirus, 2005-16: an epidemiological analysis of data collected from the NoroNet network. Lancet Infect Dis., 2018;18(5):545–553. 335. Verhoef L, Koopmans M, VAN Pelt W, et al. The estimated disease burden of norovirus in The Netherlands. Epidemiol Infect., 2013;141(3):496–506.
35. Verstraeten T, Cattaert T, Harris J, et al. Estimating the Burden of Medically Attended Norovirus Gastroenteritis: Modeling Linked Primary Care and Hospitalization Datasets. J Infect Dis., 2017;216(8):957–965.
36. Vinjé J. Advances in laboratory methods for detection and typing of norovirus. J Clin Microbiol., 2015;53(2):373–381.
37. Wollants E, De Coster S, Van Ranst M, et al. A decade of norovirus genetic diversity in Belgium. Infect Genet Evol., 2015;30:37–44.
Štítky
Hygiene and epidemiology Medical virology Clinical microbiologyČlánok vyšiel v časopise
Epidemiology, Microbiology, Immunology
2022 Číslo 2
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