New classes of antidiabetic drugs: DPP4 inhibitors and SGLT2 inhibitors in the treatment of a patient with type 2 diabetes and obesity

Česká verzia

Authors: Vladimír Uličiansky
Authors place of work: Via medica, s. r. o.
Published in the journal: Forum Diab 2016; 5(1): 17-22
Category: Topic

Summary

Dipeptidyl peptidase 4 (DPP4) inhibitors (sitagliptin, vildagliptin, saxagliptin, linagliptin, alogliptin) and sodium glucose cotransporter 2 (SGLT2) inhibitors (dapagliflozin, canagliflozin, empagliflozin) are new therapies for type 2 diabetes mellitus. They can be used alone or in combination with other glucose-lowering agents. DPP4 inhibitors exert antihyperglycemic effects by inhibiting DPP4 and thereby enhancing levels of GLP-1. DPP-4 inhibitors are weight neutral. SGLT2 inhibitors have a glucosuric effect that results in decreased HbA_1c, weight and systolic BP. The differing modes of actions of these therapies produce varied efficacy and tolerability profiles and additional treatment benefits beyond glycemic control.

Key words:
type 2 diabetes – DPP4 inhibitors – SGLT2 inhibitors – body weight

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