The metabolic syndrome and cardiometabolic comorbidities of psoriasis

Česká verzia

Authors: Karolína Vorčáková; Tatiana Péčová; Juraj Péč
Authors place of work: Dermatovenerologická klinika LF UK v Martine
Published in the journal: Forum Diab 2016; 5(1): 50-54
Category: Topic

Summary

Chronic plaque psoriasis is a chronic erythematosquamous disease which affects 2–3 % of the population. In the etiopathogenesis of moderate to severe psoriasis a large amount of proinflammatory cytokines (TNF alpha, IL6, IL17, IL20, IL23) is produced which then affect other organs and results in chronic systemic inflammation. Moderate to severe psoriasis is more frequently associated with cardiometabolic comorbidities the most significant of which is the metabolic syndrome. Etiopathogenesis of psoriasis is linked to that of the metabolic syndrome. The diseases have a common genetic basis and produce mutually stimulating cytokines. The whole cycle of proinflammatory cytokines contributes to a higher cardiovascular risk, mainly in young patients with severe disorders. Early commencement of systemic and biological treatment of psoriasis, education and rigorous evaluation of patients’ comorbidities can prevent development of the metabolic syndrome and increased cardiovascular risk.

Key words:
biological treatment – cardiovascular risk – metabolic syndrome – psoriasis

Zdroje

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