#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

What is actually the cardiovascular risk related to type 2 diabetes?


Authors: Ivan Tkáč
Authors place of work: IV. interná klinika UPJŠ LF a UNLP Košice
Published in the journal: Forum Diab 2019; 8(3): 170-173
Category: Review Article

Summary

Cardiovascular risk assessment by SCORE tables is used in subjects without diabetes. Even the latest recommendations of the European Cardiology Society (ESC) assess the cardiovascular (CV) risk in patients with based on the expert consensus and not on the basis of the risk calculated from the tables. The paper demonstrates the risk of developing major CV events and CV mortality observed in studies with SGLT2 inhibitors and GLP1 receptor agonists. In all studies where an effect on the primary composite outcome was observed, the 10-year risk of CV mortality was greater than 10 % and the risk of developing major CV events was greater than 25 %, which corresponds to a very high SCORE risk. The closest to the characteristics of the so-called general population of patients with diabetes in clinical practice was that of the REWIND study that compared add-on therapy with a GLP1 receptor agonist dulaglutide with placebo.

Keywords:

cardiovascular risk – clinical studies – GLP1 receptor agonists – SGLT2 inhibitors – type 2 diabetes


Zdroje
  1. Haffner SM, Lehto S, Rönnemaa T et al. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998; 339(4): 229–234. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJM199807233390404>.
  2. Piepoli MF, Hoes AW, Agewal S et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts)Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J 2016; 37(29): 2315–2381. Dostupné z DOI: <http://dx.doi.org/10.1093/eurheartj/ehw106>.
  3. Cosentino F, Grant PJ, Aboyans V et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J 2019. pii: ehz486. Dostupné z DOI: <http://dx.doi.org/10.1093/eurheartj/ehz486>.
  4. Wiviott SD, Raz I, Bonaca MP et al. Dapagliflozin and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2019; 380(4): 347–357. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1812389>.
  5. Neal B, Perkovic V, Mahaffey KW et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 2017; 377(7): 644–657. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1611925>.
  6. Zinman B, Wanner C, Lachin JM et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 2015; 373: 2117–2128. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1504720>.
  7. Gerstein HC, Calhoun HM, Dagenais GR, et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial. Lancet 2019; 394(10193): 121–130. Dostupné z DOI: <http://dx.doi.org/ 10.1016/S0140–6736(19)31149–3>.
  8. Pfeffer MA, Claggett B, Diaz R et al. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 2015; 373(23): 2247–2257. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1509225>.
  9. Hernandez AF, Green JB, Janmohamed S et al. Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular diesease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial. Lancet 2018; 392(10157): 1519–1529. Dostupné z DOI: <http://dx.doi.org/10.1016/S0140–6736(18)32261-X>.
  10. Marso SP, Daniels GH, Brown-Frandsen K et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2016; 375(4): 311–322. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1603827>.
  11. Marso SP, Bain SC, Consoli A et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med 2016; 375(19): 1834–1844. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1607141>.
  12. Holman RR, Bethel MB, Mentz RJ et al. Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes. N Engl J Med 2017; 377(13): 1228–1239. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1612917>.
  13. Birkeland KI, Jørgensen ME, Carstensen B et al. Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis. Lancet Diabetes Endocrinol 2017; 5(9): 709–717. Dostupné z DOI: <http://dx.doi.org/10.1016/S2213–8587(17)30258–9>.
  14. Drucker DJ. The ascending GLP-1 road from clinical safety to reduction of cardiovascular complications. Diabetes 2018; 67(9): 1710–1719. Dostupné z DOI: <http://dx.doi.org/10.2337/dbi18–0008>.
Štítky
Diabetology Endocrinology Internal medicine
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#