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Diabetes mellitus and pulmonary arterial hypertension


Authors: Bibiána Kafková
Authors place of work: I. kardiologická klinika LF UPJŠ v Košiciach a VÚSCH a. s., Košice
Published in the journal: Forum Diab 2021; 10(2): 103-107
Category:

Summary

Pulmonary arterial hypertension is a progressive disorder characterized by pathological remodeling of the pulmonary vasculature, abnormally elevated pressure in pulmonary circulation, leading do right ventricular failure and death. Glucose intolerance and insulin resistance are increasingly thought to influence pathogenesis of pulmonary arterial hypertension, development of right ventricular dysfunction and prognosis of the patient. Modification of risk factors for diabetes and targeted treatment of diabetes mellitus if it develops, may delay the progression of pulmonary arterial hypertension and improve patient quality of life.

Keywords:

diabetes mellitus – heart failure – pulmonary arterial hypertension – right ventricle


Zdroje

1. Simmnoneau G, Montani D, Celermajer DS et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Resp J 2019; 53(1): 1801913. Dostupné z DOI: <http://dx.doi.org/10.1183/13993003.01913–2018>.

2. Humbert M, Guignabert C, Bonnet S et al. Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives. Eur Respir J 2019; 53(1): 1801887. Dostupné z DOI: <http://dx.doi.org/10.1183/13993003.01887–2018>.

3. Hoeper M, Gibbs S. The changing landscape of pulmonary arterial hypertension and implication for patient care. Eur Resp J 2014; 23(134): 450–457. Dostupné z DOI: <http://dx.doi.org/10.1183/09059180.00007814>.

4. Rich S, Dantzker DR, Ayres SM et al. Primary pulmonary hypertension. A national prospective study. Annal Intern Med 1987; 107(2): 216– 223. Dostupné z DOI: <http://dx.doi.org/10.7326/0003–4819–107–2-216>.

5. Ling Y, Johnson MK, Kiely DG et al. Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland. Am J Resp Crit Care Med 2012; 186(8): 790–796. Dostupné z DOI: <http://dx.doi.org/10.1164/rccm.201203–0383OC>.

6. Gómemez A, Bialostozky D, Zajarias A et al. Right ventricular ischemia in patients with primary pulmonary hypertension. J Am Coll Card 2001; 38(4): 1137–1142. Dostupné z DOI:<http://dx.doi.org/10.1016/s0735–1097(01)01496–6>

7. Benson L, Brittain EL, Pugh ME et al. Impact of diabetes on survival and right ventricular compensation in pulmonary arterial hypertension. Pulm Circ 2014; 4(2): 311–318. Dostupné z DOI: <http://dx.doi.org/10.1086/675994>.

8. Grinnan D, Farr G, Fox A et al. The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension. J Diabetes Res 2016; 2016: 2481659. Dostupné z DOI: <http://dx.doi.org/10.1155/2016/2481659>.

9. Williams SB, Goldfine AB, Timimi FK et al. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 1998; 97(17): 1695–1701. Dostupné z DOI: <http://dx.doi.org/10.1161/01.cir.97.17.1695>.

10. Callaghan MJ, Ceradini DJ, Gurtner GC. Hyperglycemia-induced reactive oxygen species and impaired endothelial progenitor cell function. Antioxid Redox Signal 2005; 7(11–12): 1476–1482. Dostupné z DOI: <http://dx.doi.org/10.1089/ars.2005.7.1476>.

11. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414(6865): 813–820. Dostupné z DOI: <http://dx.doi.org/10.1038/414813a>.

12. Kizub IV, Klymenko KI, Soloviev AI. Protein kinase C in enhanced vascular tone in diabetes mellitus. Int J Cardiol 2014; 174(2): 230– 242. Dostupné z DOI: Dostupné z DOI: <http://dx.doi.org/10.1016/j.ijcard.2014.04.117>.

13. West J, Niswender KD, Johnson JA et al. A potential role for insulin resistance in experimental pulmonary hypertension. Eur Resp J 2013; 41(4): 861–871. Dostupné z DOI: <http://dx.doi.org/10.1183/09031936.00030312>.

14. Clemmer JS, Xiang L, Lu S et al. Hyperglycemia-mediated oxidative stress increases pulmonary vascular permeability. Microcirculation 2016; 23(3): 221–229. Dostupné z DOI: <http://dx.doi.org/10.1111/micc.12267>.

15. Whitaker ME, Vineet N, Shripad S et al. Diabetes mellitus associates with increased right ventricular afterload and remodeling in pulmonary arterial hypertension. Am J Med 2018; 131(6): 702.e7–702.e13. Dostupné z DOI: <10.1016/j.amjmed.2017.12.046>

16. Vonk NA, Chin KM, Haddad F et al. Pathophysiology of the right ventricleand of the pulmonary circulation in pulmonary hypertension: an update. Eur Respir J 2019; 53(1): 1801900. Dostupné z DOI: <http://dx.doi.org/10.1183/13993003.01900–2018>.

17. Vonk NA, Westerhof BE, Westerhof N. The Relationship Between the Right Ventricle and its Load in Pulmonary Hypertension. J Am Coll Cardiol 2017; 69(2): 236–243. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jacc.2016.10.047>.

18. Widya RL, Van der Meer RW, Smit JW et al. Right ventricular involvement in diabetic cardiomyopathy. Diabetes Care 2013; 36(2): 457– 462. Dostupné z DOI: <http://dx.doi.org/10.2337/dc12–0474>.

19. Tadic M, Celic V, Cuspidi C et al. Right heart mechanics in untreated normotensive patients with prediabetes and type 2 diabetes mellitus: a two- and three-dimensional echocardiographic study. J Am Soc Echocardiogr2015; 28(3): 317–327. Dostupné z DOI: <http://dx.doi.org/10.1016/j.echo.2014.11.017>.

20. Benson L, Brittain EL, Pugh ME et al. Impact of diabetes on survival and right ventricular compensation in pulmonary arterial hypertension. Pulm Circ 2014; 4(2): 311–318. <http://dx.doi.org/10.1086/675994>.

21. Abernethy AD, Stackhouse K, Hart S et al. Impact of diabetes in patients with pulmonary hypertension. Pulm Circ 2015; 5(1): 117–123. Dostupné z DOI: <http://dx.doi.org/10.1086/679705>.

22. Vonk NA, Haddad F, Chin KM et al. Right Heart Adaptation to Pulmonary Arterial Hypertension: Physiology and Pathobiology. J Am Coll Cardiol 2013; 62(25 Suppl): D22-D33. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jacc.2013.10.027>.

23. Nunoda SI, Genda A, Sugihara N et al. Quantitative approach to the histopathology of the biopsied right ventricular myocardium in patients with diabetes mellitus. Heart Vessels 1985; 1(1): 43–47. Dostupné z DOI: <http://dx.doi.org/10.1007/BF02066486>.

24. Kang Y, Wang S, Huang J et al. Right ventricular dysfunction and remodeling in diabetic cardiomyopathy. Am J Physiol Heart Circ Physio 2019; 316(1): H113-H122. Dostupné z DOI: <http://dx.doi.org/10.1152/ajpheart.00440.2018>.

25. Hua H, Goldberg HJ, Fantus IG et al. High glucose-enhanced mesangial cell extracellular signal—regulated protein kinase activation and α1(IV) collagen expression in response to endothelin-1: role of specific protein kinase C isozymes. Diabetes 2001; 50(10): 2376–2383. Dostupné z DOI: <http://dx.doi.org/10.2337/diabetes.50.10.2376>.

26. Lang IM, Palazzini M. The burden of comorbidities in pulmonary arterial hypertension. Eur Heart J Suppl 2019; 21(Suppl K): K21-K28. Dostupné z DOI: <http://dx.doi.org/10.1093/eurheartj/suz205>.

Štítky
Diabetology Endocrinology Internal medicine

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Forum Diabetologicum

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