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preLekára.sk / Journals / Forum Diabetologicum / 2021 - Supplementum 1

Antidiabetic treatment in prevention of atherosclerosis: last decade

Česká verzia

Authors: Emil Martinka 1,2
Authors place of work: Národný endokrinologický a diabetologický ústav, n. o., Ľubochňa 1;  Fakulta zdravotníckych vied Piešťany, Univerzita Sv. Cyrila a Metoda, Trnava 2
Published in the journal: Forum Diab 2021; 10(Supplementum 1): 16-27
Category:

Summary

In the last five years, the results of several studies aimed at testing the cardiovascular (CV) safety (so-called “CVOT” studies) of newer antidiabetic drug users have been published, which have attracted special attention and become one of the most important in diabetology. Indeed, they have shown that drugs from the group of SGLT-2 cotransport inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP1-RA) are not only cardiovascular safe, but their addition to treatment is associated with a significant reduction in cardiovascular and renal morbidity and mortality even with previously complexive cardioprotective treatment. In the review article, we analyze the results of the most important randomized controlled trials, as well as a study from real practice, as well as the implementation of these findings into therapeutic recommendations.

Keywords:

antidiabetic treatment – Atherosclerosis – cardiovascular diseases – dipeptidyl peptidase 4 inhibitors – GLP1 receptor agonists – SGLT-2 cotransport inhibitors

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