Finerenone in the treatment of chronic kidney disease and type 2 diabetes mellitus and case report

Česká verzia

Authors: Tímea Blichová ^1,2; Patrícia Kleinová ^1,2; Matej Vnučák ^1,2; Karol Graňák ^1,2; Monika Beliančinová ^1,2; Ivana Dedinská ^1,2
Authors place of work: I. interná klinika JLF UK a UNM, Martin ¹; Transplantačno-nefrologické oddelenie UNM, Martin ²
Published in the journal: Forum Diab 2024; 13(2): 62-66
Category: Review Article

Summary

Diabetes mellitus is the most common cause of chronic kidney disease (CKD), which progressively leads to end-stage renal failure with the need for renal replacement. Patients with type 2 diabetes mellitus (T2DM) are at higher risk of cardiovascular events (myocardial infarction, stroke, arrhythmias and heart failure] and progression to chronic kidney disease. The aim is to prevent these complications by lifestyle changes, regular monitoring of blood pressure and glycemic levels, as well as the use of cardioprotective and nephroprotective drugs. Finerenone, as a non-steroidal selective mineralocorticoid receptor antagonist, represents, together with angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARBs) and sodium-glucose cotransporter 2 inhibitors (SGLT2i), the mainstay of treatment in patients with T2DM and CKD to prevent the progression of chronic kidney disease and prevent cardiovascular events. This article provides more information on the mechanism of action of finerenone, the results of the finerenone trials (FIDELIO-DKD and FIGARO-DKD), and the indication criteria that are valid in Slovakia and must be met before finerenone can be added to the treatment regimen. Finally, we present a short case report of our patient showing the effect of finerenone treatment in practice.

Keywords:

diabetes mellitus – chronic kidney disease (CKD) – finerenone – mineralocorticoid receptor antagonist

Zdroje

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