Enteropathy-Associated Non-Hodgkin T-Lymphoma as a Complication of Late Diagnosis of Celiac Disease in a Geriatric Patient
Authors:
P. Kružliak; E. Čičmancová
Authors place of work:
Interné oddelenie NsP Bojnice
Published in the journal:
Gastroent Hepatol 2010; 64(1): 7-11
Category:
Case Report
Summary
Enteropathy-associated non-Hodgkin T-lymphoma (EATL) is a tumor of intraepithelial T-lymphocytes of the small intestine with heterogeneous morphologic and clinical picture dependent on the degree of malignant transformation of the cells. This disease is presented as a malabsorption of mostly celiac origin which is supposed to be a precancerosis of this tumorous condition. The risk factors of the malignant complication development in patients with celiac are the gluten exposure time, celiac diagnosed in older patients and celiac refractory to the treatment. It is a serious disease with poor prognosis and high mortality. The authors present the clinical case of a patient who was diagnosed with celiac late and at a high age, complicated by the occurrence of EATL. This paper aims to point out the significance of celiac as precancerosis in patients of intermediate and older age and the alarming situation in celiac epidemiology related to the distinctive underdiagnosis of this disease in the population.
Key words:
celiac disease – precancerosis – enteropathy-associated non-Hodgkin T-lymphoma (EATL)
Zdroje
1. Domizio P, Owen R, Shepherd N et al. Primary lymphoma of the small intestine: A clinicopathological study of 119 cases. Am J Surg Pathol 1993; 17(5): 429–442.
2. Farrell RJ, Kelly CP. Celiac sprue. N Engl J Med 2002; 346(3): 180–188.
3. Green PH, Jabri B. Coeliac disease. Lancet 2003; 362(9381): 383–391.
4. Holmes G, Prior P, Lane M et al. Malignancy in celiac disease. Gut 1989; 30(3): 333–338.
5. Lukáš M. Celiakie-glutenová enteropatie. Vnitř Lék 2003; 49(6): 449–451.
6. Pekárková B, Pekárek B, Kabátová J. Racionálna diagnostika a liečba celiakie. Met Lis 2009; 13(1): 1–8.
7. Robins G, Howdle PD. Advance in celiac disease. Curr Opin Gastroenterol 2004; 20(2): 95–103
8. Tomíška M, Vášová I, Adam Z et al. Primární lymfomy zažívacího traktu I.: Klasifikace, patogeneze a diagnostika. Klin Onkol 2002; 15(2): 47–57.
9. Tomíška M, Vášová I, Adam Z et al. Primární lymfomy zažívacího traktu II.: Léčba a prognóza. Klin Onkol 2002; 15(3): 86–92.
Štítky
Paediatric gastroenterology Gastroenterology and hepatology SurgeryČlánok vyšiel v časopise
Gastroenterology and Hepatology
2010 Číslo 1
- Spasmolytic Effect of Metamizole
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
- Metamizole in perioperative treatment in children under 14 years – results of a questionnaire survey from practice
- Current Insights into the Antispasmodic and Analgesic Effects of Metamizole on the Gastrointestinal Tract
- Obstacle Called Vasospasm: Which Solution Is Most Effective in Microsurgery and How to Pharmacologically Assist It?
Najčítanejšie v tomto čísle
- The Diagnosis and Treatment of Globus Pharyngeus
- Recommendation for Vaccinations in Patients with Crohn’s Disease and Ulcerative Colitis on Immunosuppressive and/or Biological Therapy
- Neuroendocrine Tumors of the Large Bowel
- Enteropathy-Associated Non-Hodgkin T-Lymphoma as a Complication of Late Diagnosis of Celiac Disease in a Geriatric Patient