Quantitative testing in colorectal cancer screening – a view of the near future

Česká verzia

Authors: J. T. Kovářová
Authors place of work: IV. interní klinika VFN a 1. LF UK Praha
Published in the journal: Gastroent Hepatol 2011; 65(2): 90-93
Category: Clinical and Experimental Gastroenterology: Review Article

Summary

The author offers a systematic account of the new generation of quantitative immunochemical fecal occult blood tests, and outlines a scheme for their integration into the existing Czech program that screens for colorectal cancer. The characteristics of the quantitative immunochemical test (q-FIT) are described, as well as the types of the fecal occult test (FOBT), and their advantages and disadvantages, together with possible ways of the incorporating q-FIT into the colorectal cancer screening program in the Czech Republic. The inclusion of q-FIT in the Czech colorectal cancer screening program, combined with the existing primary screening colonoscopy, could make a contribution to effectiveness.

Key words:
cut off – quantitative immunochemical test – colorectal cancer – screening – fecal occult blood test

Zdroje

1. Dušek L, Abrahámová J, Mužík J et al. Populační odhady počtu nemocných s kolorektálním karcinomem v ČR – jeden z nástrojů hodnocení včasné diagnostiky časných stadií a rekurence onemocnění. Farmakoterapie – speciální příloha Kolorektální karcinom 2009; 11–20.

2. Zavoral M, Suchanek S, Zavada F et al. Colorectal cancer screening in Europe. World J Gastroenterol 2009; 15(47): 5907–5915.

3. Rossum LG, Rijn AF, Laheij RJ et al. Random comparison of guaiac and immunochemical fecal occult blood tests for colorectal cancer in a screening population. Gastroenterology 2008; 135(1): 82–90.

4. Levi Z, Rozen P, Hazazi R et al. A Quantitative immunochemical fial occult blood test for colorectal neoplasia. Ann Intern Med 2007; 146(4): 244–255.

5. Dubská L, Nechvátal J. Kvantitativní stanovení hemoglobinu ve stolici, Laboratorní technologie. http://www.stapro.cz/bullfons/32009/labo1.pdf

6. Mandel JS, Bond JH, Church TR et al. Reducing mortality from colorectal cancer by screening for fecal occult blood. N Engl J Med 1993; 329(9): 672.

7. Mandel JS, Church TR, Bond JH et al. The effect of fecal occult-blood screening on the incidence of colorectal cancer. N Engl J Med 2000; 343(22): 1603–1607.

8. Hardcastle JD, Chamberlain JO, Robinson MH et al. Randomised controlled trial of faecal-occult-blood screening for colorectal cancer. Lancet 1996; 348(9040): 1472–1477.

9. Hundt S, Haug U, Brenner H. Comparative evaluation of immunochemical fecal occult blood tests for colorectal adenoma detection. Ann Intern Med 2009; 150(3): 162–169.

10. Vilkin A, Rozen P, Levi Z et al. Performance characteristic and evaluation of an automated-developed and quantitative, immunochemical, fecal occult blood screening test. Am J Gastroenterol 2005; 100(11): 2519–2525.

11. Grazzini G, Visioli CB, Zorzi M et al. Immunochemical faecal occult blood test: number of samples and positivity cutoff. What is the best strategy for colorectal cancer screening? Br J Cancer 2009; 100(2): 259–265.

12. Rossum LG, Rijn AF, Oijen MG et al. False negative fecal occult blood test due to delayed sample return in colorectal cancer screening. Int J Cancer 2009; 125(4): 746–750.

13. Grazzini G, Ventura L, Zappa MS et al. Influence of seasonal variations in ambient temperatures on performance of immunochemical faecal occult blood test for colorectal cancer screening: observational study from the Florence distrikt. Gut 2010; 59(11): 1511–1515.

14. Levi Z, Hazazi R, Rozen P et al. A quantitative immunochemical faecal occult blood test is more efficient for detecting significant colorectal neoplasia than a sensitive guaiac test. Aliment Pharmacol Ther 2006; 23(9): 1359–1364.