Current scientific background of Crohn’s Disease Exclusion Diet (CDED)

Česká verzia

Authors: El-Lababidi N.
Authors place of work: Centrum dětské gastroenterologie, hepatologie a výživy, Klinika dětského a dorostového lékařství 1. LF UK a VFN v Praze
Published in the journal: Gastroent Hepatol 2020; 74(3): 240-245
Category: IBD: Review Article
doi: https://doi.org/10.14735/amgh2020240

Summary

According to current European Crohn’s and Colitis Organisation (ECCO) and European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) joint guidelines, exclusive enteral nutrition (EEN) is the method of choice for the induction of remission of luminal Crohn’s disease (CD) in paediatric patients. The main limitations of EEN are its monotony and palatability. Factors of the Western diet that could cause gut dysbiosis, dysregulation of immune mechanisms and induce inflammation in the intestinal mucosa have been identified. Eliminating these dietary factors should induce remission of CD. Crohn’s disease exclusion diet (CDED) is based on that principle. The data show that in the 6^th week of treatment, CDED with partial enteral nutrition (PEN) is equally effective but better tolerated than EEN. The induction and maintenance of remission in the 12^th week of therapy is statistically significantly better when using CDED with PEN. CDED is a very promising concept in the induction of remission of mild to moderate intraluminal CD.

Keywords:

Crohn’s disease – Crohn’s disease exclusion diet – adherence – gut microbiota

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