Whipple disease – two case reports

Česká verzia

Authors: Šurinová J.; Straka L.
Authors place of work: Gastroenterologická ambulance, Uherskohradišťská nemocnice a. s.
Published in the journal: Gastroent Hepatol 2020; 74(4): 334-338
Category:
doi: https://doi.org/10.14735/amgh2020334

Summary

We present two cases of our patients examined for weight loss, arthralgia and diarrhea, who were diagnosed with Whipple disease. Whipple disease is a rare chronic systemic illness, nevertheless it can be found in the ordinary clinical practice. Symptoms of this disease are not generally specific ones. The diagnosis is based on gastroscopic findings of duodenal mucosal atrophy with enlarged lymphatics, typical histological findings and polymerase chain reaction verification of Tropheryma whipplei. If we consider the disease in the differential diagnosis, an antibiotic treatment is almost always successful. To reduce the risk of relapse, such treatment should be carried out on a long-term basis.

Conflict of Interest: The authors declare that the article/manuscript complies with ethical standards, patient anonymity has been respected, and they state that they have no financial, advisory or other commercial interests in relation to the subject matter.

Publication Ethics: This article/manuscript has not been published or is currently being submitted for another review. The authors agree to publish their name and e-mail in the published article/ manuscript.

Dedication: The article/manuscript is not supported by a grant nor has it been created with the support of any company.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for bio medical papers.

Keywords:

endoscopy – Whipple disease – malabsorption syndromes – Tropheryma whipplei

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