Pharmacological characteristics of subcutaneously administered monoclonal antibodies

Česká verzia

Authors: K. Urbánek
Authors place of work: Ústav farmakologie LF UP a FN Olomouc
Published in the journal: Gastroent Hepatol 2023; 77(6): 539-543
Category: IBD
doi: https://doi.org/10.48095/ccgh2023539

Summary

Subcutaneous administration is a simple method of parenteral administration with a minimum of possible complications, also suitable for home treatment. Moreover, it can be used to influence the pharmacokinetics of the administered drug. For therapeutically used monoclonal antibodies, it brings several advantages in terms of simplifying treatment and improving patient’s adherence. In addition, it appears that by targeting pharmacokinetic parameters, lower immunogenicity, and achievement of pharmacokinetic-pharmacodynamic targets can be achieved and thus, likely improve treatment outcomes.

Keywords:

monoclonal antibodies – pharmacokinetics – pharmacodynamics – subcutaneous administration

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