Regulatory T cells and their prognostic value for head and neck oncology

Česká verzia

Authors: J. Bouček ^1,2; J. Betka ^1,2; J. Kastner ¹; J. Betka ¹; T. Eckschlager ³; B. Říhová ²
Authors place of work: Klinika otorhinolaryngologie a chirurgie hlavy a krku, 1. LF UK a FN v Motole, Katedra otorhinolaryngologie IPVZ, Praha Přednosta: prof. MUDr. Jan Betka, DrSc. ¹; Mikrobiologický ústav AV ČR, Sektor Imunologie a gnotobiologie, Praha Vedoucí: Prof. RNDr. Blanka Říhová, DrSc. ²; Klinika dětské hematologie a onkologie, 2. LF UK, Praha Přednosta: prof. MUDr. Jan Starý, DrSc. ³
Published in the journal: Prakt. Lék. 2009; 89(1): 16-19
Category: Various Specialization

Summary

Regulation of immune responses, including anti-cancer immunosurveillance, plays an important role in the maintenance of homeostasis. Many of these key mechanisms have been described in last twenty years. Regulatory T cells (Treg, CD4⁺CD25⁺Foxp3⁺) have been shown to be one of the most important components in the regulation of immune responses. Treg numbers have been shown to increase in the peripheral circulation of patients with different types of tumors. This has been documented in correlation with the progression of head and neck squamous cell carcinoma (HNSCC).

Keywords:
regulatory T cells, head and neck squamous cell carcinoma, lymphocyte subpopulation, prognosis, early recurence.

Zdroje

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