Microbiome, respiratory allergy, and a perspective of treatment
Authors:
N. Lukán 1; A. Chmelárová 2
Authors place of work:
IV. interná klinika UPJŠ LF a UNLP, Košice
Prednosta: prof. MUDr. Ivan Tkáč, CSc.
1; Ústav experimentálnej medicíny UPJŠ LF Košice
Prednosta: MVDr. Alojz Bomba, DrSc.
2
Published in the journal:
Prakt. Lék. 2015; 95(3): 110-113
Category:
Of different specialties
Summary
At present, many scientific institutions focus their attention on microbiome and its influence on human health. It is assumed that changes in microbiome are also responsible for pathogenesis of respiratory diseases (COPD, cystic fibrosis), as well as for pathogenesis of respiratory allergies (rhinitis, asthma). Micro-world regulates the homeostasis by (1) immunologic, (2) metabolic mechanisms and by (3) control chronic inflammatory processes.
Contemporary knowledge on dysbiosis in chronic diseases opens new perspectives for treatment by modulation of altered state. Schemes target the dysbiotic microflora as potential option for such treatment. Probiotics, prebiotics, combinatory approaches and perspectively gut microbiota transplantation are considered.
The main aim of the review is to show the new perspectives of respiratory disease control, especially respiratory allergies by the regulation of the microbiome and the homeostatic processes in the human body.
Keywords:
microbiome – allergy – respiratory organs – treatment
Zdroje
1. Abeles SR, Robles-Sikisaka R, Ly M, et al. Human oral viruses are personal, persistent and gender-consistent. ISME J 2014; 8(9): 1753–1767.
2. WHO. Asthma. WHO Fact sheet N°307 (update Nov 2013). Dostupný na: http://www.who.int/mediacentre/factsheets/fs307/en/.
3. Azad MB, Coneys JG, Kozyrskyj AL, et al. Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis. Allergy Asthma Clin Immunol 2014; 10(Suppl 1): A25.
4. de Kivit S, Saeland E, Kraneveld AD, et al. Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans. Allergy 2012; 67(3): 343–352.
5. Elazab N, Mendy A, Gasana J, et al. Probiotic administration in early life, atopy, and asthma: a meta-analysis of clinical trials. Pediatrics 2013; 132(3): e666–e676.
6. Emuzyte R, Firantiene R, Petraityte R, Sasnauskas K. Human rhinoviruses, allergy, and asthma: a clinical approach. Medicina (Kaunas) 2009; 45(11): 839–847.
7. Erb-Downward JR, Thompson DL, Han MK, et al. Analysis of the lung microbiome in the „healthy“ smoker and in COPD. PLoS One 2011; 6(2): e16384.
8. Gollwitzer ES, Marsland BJ. Microbiota abnormalities in inflammatory airway diseases - potential for therapy. Pharmacol Ther 2014; 141(1): 32–39.
9. Herbst T, Sichelstiel A, Schär C, et al. Dysregulation of allergic airway inflammation in the absence of microbial colonization. Am J Respir Crit Care Med 2011; 184(2): 198–205.
10. Hilty M, Burke C, Pedro H, et al. Disordered microbial communities in asthmatic airways. PLoS One 2010; 5(1): e8578.
11. Charlson ES, Bittinger K, Chen J, et al. Assessing bacterial populations in the lung by replicate analysis of samples from the upper and lower respiratory tracts. PLoS One 2012; 7(9): e42786.
12. Ivory K, Chambers SJ, Pin C, Prieto E, et al. Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis. Clin Exp Allergy 2008; 38(8): 1282–1289.
13. Kim SO, Ah YM, Yu YM, et al. Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials. Ann Allergy Asthma Immunol 2014; 113(2): 217–226.
14. Marsland BJ, Gollwitzer ES. Host-microorganism interactions in lung diseases. Nat Rev Immunol 2014; 14(12): 827–835.
15. Molyneaux PL, Mallia P, Cox MJ, et al. Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 188(10): 1224–1231.
16. Nembrini C, Sichelstiel A, Kisielow J, et al. Bacterial-induced protection against allergic inflammation through a multicomponent immunoregulatory mechanism. Thorax 2011; 66(9): 755–763.
17. Ouwehand AC, Nermes M, Collado MC, et al. Specific probiotics alleviate allergic rhinitis during the birch pollen season. World J Gastroenterol 2009 15(26): 3261–3268.
18. Schram D, Doekes G, Boeve M, et al. PARSIFAL Study Group. Bacterial and fungal components in house dust of farm children, Rudolf Steiner school children and reference children - the PARSIFAL Study. Allergy 2005; 60(5): 611–618.
19. Turnbaugh PJ, Ley RE, Hamady M, et al. The human microbiome project: exploring the microbial part of ourselves in a changing world. Nature 2007; 449(7164): 804–810.
Štítky
General practitioner for children and adolescents General practitioner for adultsČlánok vyšiel v časopise
General Practitioner
2015 Číslo 3
- Advances in the Treatment of Myasthenia Gravis on the Horizon
- Memantine Eases Daily Life for Patients and Caregivers
- What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?
- Spasmolytic Effect of Metamizole
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
Najčítanejšie v tomto čísle
- Comparison of risks from smoking cigarettes and water pipe
- Aortic dissection in routine practice
- Reliability of clinical indicators of neonatal sepsis
- Microbiome, respiratory allergy, and a perspective of treatment