Dark lesions in the oral cavity – differential diagnosis
Authors:
V. Radochová 1; R. Slezák 1; M. Šembera 1; J. Radocha 2
Authors place of work:
Stomatologická klinika, Lékařská fakulta Univerzity Karlovy a Fakultní nemocnice, Hradec Králové, Přednosta: doc. MUDr. Radovan Slezák, CSc.
1; IV. interní hematologická klinika, Přednosta: doc. MUDr. Pavel Žák, Ph. D.
2
Published in the journal:
Prakt. Lék. 2018; 98(6): 239-245
Category:
Reviews
Summary
Oral mucosal disorders are represented by diseases of various origin and severity. White lesions, redness and erosions are among the most frequent ones. Dark oral lesions can be observed less frequently. These lesions vary from asymptomatic oral pigmentations to serious cancers. Dark lesions frequently lead to patient’s anxiety and fear from cancer. The dark lesions are serious only infrequently and most often benign. The dark lesion can be also a sign of systemic disorder. General practitioner can bet he first physician to observe this kind of lesions or can be asked about the origin of the lesion by the patient. The aim of this review is to introduce the topic of dark oral lesions to general physicians.
Keywords:
oral pigmentations – melanotic macula – malignant melanoma – amalgam tattoo – Peutz-Jeghers syndrome
Zdroje
1. Alawi F. Pigmented lesions of the oral cavity: an update. Dent Clin North Am 2003; 57(4): 699–710.
2. Axéll T, Hedin CA. Epidemiologic study of excessive oral melanin pigmentation with special reference to the influence of tobacco habits. Scand J Dent Res 1988; 90(6): 434–442.
3. Buchner A, Hansen LS. Pigmented nevi of the oral mucosa: a clinicopathologic study of 36 new cases and review of 155 cases from the literature. Part II: Analysis of 191 cases. Oral Surg Oral Med Oral Pathol 1987; 63(6): 676–682.
4. Buchner A, Merrell PW, Carpenter WM. Relative frequency of solitary melanocytic lesions of the oral mucosa. J Oral Pathol Med 2004; 33(9): 550–557.
5. Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998; 83(8): 1664–1678.
6. Dereure O. Drug-induced skin pigmentation. Epidemiology, diagnosis and treatment. Am J Clin Dermatol 2001; 2(4): 253–262.
7. Dorji T, Cavazza A, Nappi O, et al. Spitz nevus of the tongue with pseudoepitheliomatous hyperplasia: report of three cases of a pseudomalignant condition. Am J Surg Pathol 2002; 26(6): 774–777.
8. Eisen D. Disorders of pigmentation in the oral cavity. Clin Dermatol 2000; 18(5): 579–587.
9. El-Naggar A, Chan J, Grandis J, et al. (eds.) WHO classification of head and neck tumours. 4th ed. Lyon: International Agency for Research on Cancer 2017.
10. Ferreira L, Jham B, Assi R, et al. Oral melanocytic nevi: a clinicopathologic study of 100 cases. Oral Surg Oral Med Oral Pathol Oral Radiol 2015; 120(3): 358–367.
11. Ficarra G, Shillitoe EJ, Adler-Storthz K, et al. Oral melanotic macules in patients infected with human immunodeficiency virus. Oral Surg Oral Med Oral Pathol 1990; 70(6): 748–755.
12. Gondak R-O, da Silva-Jorge R, Jorge J, et al. Oral pigmented lesions: Clinicopathologic features and review of the literature. Med Oral Patol Oral Cir Bucal 2012; 17(6): e919–924.
13. Glick M. (ed.) Burket’s Oral Medicine. 12th ed. Shelton, CT: PMPH-USA 2015.
14. Greven S, Fölster-Holst R. Peutz-Jeghers syndrome : not only a polyposis! Hautarzt 2012; 63(11): 877–879.
15. Hassona Y, Sawair F, Al-Karadsheh O, et al. Prevalence and clinical features of pigmented oral lesions. Int J Dermatol 2016; 55(9): 1005–1013.
16. Hicks MJ, Flaitz CM. Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncol 2000; 36(2): 152–169.
17. Kaugars GE, Heise AP, Riley WT, et al. Oral melanotic macules. A review of 353 cases. Oral Surg Oral Med Oral Pathol 1993; 76(1): 59–61.
18. Lampe AK, Hampton PJ, Woodford-Richens K, et al. Laugier-Hunziker syndrome: an important differential diagnosis for Peutz-Jeghers syndrome. J Med Genet 2003; 40(6): e77.
19. Lenane P, Powell FC. Oral pigmentation. J Eur Acad Dermatol Venereol 2000; 14(6): 448–465.
20. McLean N, Tighiouart M, Muller S. Primary mucosal melanoma of the head and neck. Comparison of clinical presentation and histopathologic features of oral and sinonasal melanoma. Oral Oncol 2008; 44(11): 1039–1046.
21. Meleti M, Leemans CR, Mooi WJ, et al. Oral malignant melanoma: a review of the literature. Oral Oncol 2007; 43(2): 116–121.
22. Meleti M, Mooi WJ, Casparie MK, et al. Melanocytic nevi of the oral mucosa - no evidence of increased risk for oral malignant melanoma: an analysis of 119 cases. Oral Oncol 2007; 43(10): 976–981.
23. Meleti M, Vescovi P, Mooi WJ, et al. Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the management. Oral Surg. Oral Med Oral Pathol Oral Radiol Endod 2008; 105(5): 606–616.
24. Mignogna MD, Lo Muzio L, Ruoppo E, et al. Oral manifestations of idiopathic lenticular mucocutaneous pigmentation (Laugier-Hunziker syndrome): a clinical, histopathological and ultrastructural review of 12 cases. Oral Dis 1999; 5(1): 80–86.
25. Moraes RM, Gouvêa Lima G de M, Guilhermino M, et al. Graphite oral tattoo: case report. Dermatol Online J 2015; 21(10). pii: 13030/qt0z57p9xr
26. Neville B, Damm DD, Allen C, et al. Oral and Maxillofacial Pathology. 3rd ed. St. Louis: Saunders 2009.
27. Nieman LK, Chanco Turner ML. Addison’s disease. Clin Dermatol 2006; 24(4): 276–280.
28. Nikai H, Miyauchi M, Ogawa I, et al. Spitz nevus of the palate. Report of a case. Oral Surg Oral Med Oral Pathol 1990; 69(5): 603–608.
29. Rapini RP, Golitz LE, Greer RO, et al. Primary malignant melanoma of the oral cavity. A review of 177 cases. Cancer 1985; 55(7): 1543–1551.
30. Slezák R. Malé ilustrované repetitorium. Hradec Králové: Nucleus 2004.
31. Slezák R, Dřízhal I. Atlas chorob ústní sliznice. Praha: Quintessenz 2004.
32. Slezák R, Pohnětalová D, Horáček J, Nožička Z. Melaninové hyperpigmentace ústní sliznice. LKS 1998; 8(5): 12–14.
33. Smith MH, Bhattacharyya I, Cohen DM, et al. Melanoma of the oral cavity: an analysis of 46 new cases with emphasis on clinical and histopathologic characteristics. Head Neck Pathol 2016; 10(3): 298–305.
34. Tanaka N, Mimura M, Ichinose S, et al. Malignant melanoma in the oral region: ultrastructural and immunohistochemical studies. Med Electron Microsc 2001; 34(3): 198–205.
35. Tarakji B, Umair A, Prasad D, et al. Diagnosis of oral pigmentations and malignant transformations. Singapore Dent J 2014; 35C: 39–46.
36. Tavares TS, Meirelles DP, de Aguiar MCF, Caldeira PC. Pigmented lesions of the oral mucosa: A cross-sectional study of 458 histopathological specimens. Oral Dis 2018; Jun 26. doi: 10.1111/odi.12924 [Epub ahead of print].
37. Taybos G. Oral changes associated with tobacco use. Am J Med Sci 2003; 326(4): 179–182.
38. Tomas C, Soyer P, Dohan A, et al. Update on imaging of Peutz-Jeghers syndrome. World J Gastroenterol 2014; 20(31): 10864–10875.
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