Possible uses of fecal bacteriotherapy

Česká verzia

Authors: Stebel Roman; Husa Petr
Authors place of work: Klinika infekčních chorob Lékařské fakulty Masarykovy univerzity a Fakultní nemocnice Brno
Published in the journal: Geriatrie a Gerontologie 2023, 12, č. 2: 83-87
Category: Review Article

Summary

The problematic of intestinal dysbiosis is currently an object of intensive research, alteration of microbiota is related to pathogenesis of a whole array of disease states. A certain prototype of illness at which disruption of natural balance of intestinal microbial ecosystem plays a key role is recurrent Clostridium difficile colitis. A very hopeful method having the potential to therapeutically intervene exactly at the level of altered intestinal microbiota is fecal bacteriotherapy. It is already globally established method with aim to achieve the restoration of natural microbial homeostasis in the intestine using stool of healthy donor which is transplanted into the intestines of a patient. By restoring the colonization resistance of large intestine, the transplantation of intestinal microbiota can break an imaginary vicious cycle of repeated attacks of Clostridium difficile colitis. Within secondary prophylaxis of recurrent Clostridium difficile colitis, fecal bacteriotherapy is a very effective, safe, and by patients well-tolerated method. We can see its future in both improvement of the fecal transplant administration method (including enteric capsules) and more targeted manipulation with intestinal microbiota which will lead to extension of indications by an array of other illnesses.

Keywords:

Clostridioides difficile – intestinal dysbiosis – pseudomembranous enterocolitis – faecal microbiota transplantation

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