The association of BDNF, irisin, muscle mass and strength with cognitive function in older women: how strongly these parameters predict scores on selected cognitive domain tests
Authors:
Polanská Hana 1; Jandová Tereza 1; Holá Veronika 1; Dytrtová Jaklová Jana 1; Weinerová Josefína 2; Šteffl Michal 1; Kramperová Veronika 1; Bartoš Aleš 2
Authors place of work:
Fakulta tělesné výchovy a sportu Univerzity Karlovy, Praha
1; Neurologická klinika 3. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice Královské Vinohrady, Praha
2
Published in the journal:
Geriatrie a Gerontologie 2024, 13, č. 3: 119-125
Category:
Original Article
Summary
Understanding the relationship between sensorimotor variables and exerkines related to brain function and cognition may help better understand biological ageing. The main aim of this study was to determine how strongly brain-derived neurotrophic factor (BDNF), irisin, muscle mass and muscle strength are associated and predict scores on selected cognitive domain tests in older women. Fifty seven older women (mean age 70.4 ± 4.1 years) underwent a battery of cognitive and psychological tests and measurements of isometric dynamometry and bioelectrical impedance. Serum exerkines levels were measured by enzyme-linked immunosorbent assay (ELISA). Hierarchical multiple regression models were used to test the predictions. We estimated that 46.1% of the variance in short-term memory was accounted for by serum BDNF levels, with age being the second statistically significant predictor (Beta = -0.22; p = 0.030). Lower limb strength (LLS) showed significant predictive power in both immediate (Beta = 0.39; p = 0.004) and delayed memory (Beta = 0.45; p = 0.001), serum BDNF levels were a significant predictor in delayed memory (Beta = 0.29; p = 0.048). Adding serum BDNF levels to the model showed a significant increase in predictive power of approximately 5.6% (p = 0.048) in delayed memory. Skeletal muscle index (SMI) and education level were significant predictors of mental flexibility. A strong positive association between BDNF levels, irisin, muscle strength, and cognitive function was found, with irisin and muscle strength being strong predictors of BDNF levels in older women.
Keywords:
cognitive domains, ageing, cognitive performance, cognitive function, serum, biomarkers
Zdroje
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