Some markers of cardiac and renal failure in seniors with sepsis

Czech version

Authors: David Čmejrek
Authors‘ workplace: Kardiocentrum, Stredoslovenský ústav srdcových a cievnych chorôb, Banská Bystrica, Slovenská republika
Published in: Geriatrie a Gerontologie 2025, 14, č. 1: 10-14
Category: Original Article
doi: https://doi.org/10.61568/geri/50-6457/20250217/139904

Overview

Sepsis is a life-threatening condition with organ dysfunction and dysregulated body response to infectious agents. The incidence in Europe is 3.4 million cases each year. Mortality is high and has 2 peaks – in children under the age of 5 and in the elderly. We analyzed a set of 65-years old and older pacients with sepsis (n = 32). We focused on the relationship between cardiac (NT-proBNP and troponin) and renal (urea and creatinine) indicators within the time frame of the first 72 hours after diagnosis of sepsis. We started from the assumption that the heart and kidneys are not two separate vessels, but rather two codominant permanently connected elements. We monitored relationships in 2 levels, within the cardio-renal interactions and in the cardio-reno-inflammatory complex. A positive relationship between markers in both levels was demonstrated, but their connection was not fixed, but dynamically changing, with the first 24 hours being the decisive time frame. This supports the concept of cardio-renal syndrome(KRS) type 5 as a dynamic disease. Due to the increasing data on the rising incidence of latent chronic involvement of the heart and kidneys, the question is whether CRS type 5 is a separate nosological unit or is a subtype of CRS type 1 or 3.

Keywords:

sepsis – cardial – renal and inflammatory laboratory markers – time

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