Obesity and metabolic syndrome

Česká verzia

Authors: D. Zeman
Authors place of work: II. interní klinika Lékařské fakulty MU a FN u sv. Anny, Brno, přednosta doc. MUDr. Miroslav Souček, CSc.
Published in the journal: Vnitř Lék 2005; 51(1): 72-75
Category: Reviews

Summary

Obesity is associated with insulinresistance and metabolic syndrome. The correlation of the presence of abdominal or visceral obesity defined by waist circumference with the occurence of metabolic risk factors and metabolic syndrome is more significant than body mass index. Adipocytokine secretion activity of adipose tissue participates in the pathogenesis of metabolic syndrome. External factors can significantly modify the course of metabolic syndrome disease. Weight reduction is an effective therapeutical intervention. Complex therapeutical approach includes the cognitive behavioral intervention techniques, dietotherapy, regimen exercise measures, pharmacotherapy and surgical bariatric techniques.

Key words:
obesity – visceral obesity – adipose tissue – metabolic syndrome – therapy/treatment of obesity

Zdroje

1. Abate N, Garg A. Heterogenity in tissue metabolism: causes, implications and management of regional adiposity. Prog Lipid Res 1995; 34: 53–70.

2. Gray GB. Obesity is a chronic, relapsing neurochemical disease. International Journal of Obesity 2004; 28: 34–38.

3. Hainer V, Kunešová M. Obezita. Praha: Galén 1997.

4. Kissebah AH, Krakower FR. Regional adiposity and morbidity. Physiol Rev 1994; 74: 761–811.

5. Muredach PR, Daniel J. The Metabolic Syndrom: More Than the Sum of Its parts? Circulation 2003;108: 1546–1551.

6. Nives DJ, Cnop M et al. The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat. Diabetes 2003: 52: 172–179.

7. Peter WF, Scott MG. The Metabolic Syndrom. Practical Guide to Originis and Treatment. Part I. Circulation 2003; 108: 1422–1425.

8. Scott MG, Brewer BH et al. Definition of Metabolic Syndrome, Report of the National Heart, Lung, and Blood Institute/ AHA Conference on Scientific Issues Related to Definition. Circulation 2004; 109: 433–438.

9. Scott MG, Hansen B et al. Clinical Management of Metabolic Syndrom, Report of the AHA/National Heart, Lung, and Blood Institute/ADA Conference on Scientific Issues Related to Management. Circulation 2004; 109: 551–556.

10. Svačina S, Owen K. Syndrom inzulinové rezistence. Praha: Triton 2003.