Late complications of chronic respiratory infections in patients with common variable immunodeficiency

Česká verzia

Authors: O. Kopecký ¹; Š. Lukešová ¹; V. Koblížek ³; V. Vroblová ¹; J. Novotný ²
Authors place of work: Ústav klinické imunologie a alergologie Lékařské fakulty UK a FN Hradec Králové, přednosta MUDr. Otakar Kopecký, CSc. ¹; Radiologická klinika Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Pavel Eliáš, CSc. ²; Plicní klinika Lékařské fakulty UK a FN Hradec Králové, přednosta doc. MUDr. František Salajka, CSc. ³
Published in the journal: Vnitř Lék 2006; 52(11): 1021-1029
Category: Original Contributions

Summary

Common variable immunodeficiency (CVID) is the most frequent serious humoral deficiency manifested in adulthood, and is due to acute and chronic respiratory infections which lead to respiratory failure. Retrospective analyses of 28 CVID patients were made. Mean age at time of diagnosis was 38.6 ± 18.6 years. The development of the first symptoms to the time of diagnosis was delayed 14.1 ± 10.2 years, three times longer than in other studies. Twenty-three (82.1 %) of the patients had respiratory complications. Chronic obstructive pulmonary diseases, n = 16 (57.1 %), and bronchiectasis, n = 10 (35.7 %), were the most frequent types of lung damage. In addition, two patients (7.1 %) had evidence of an interstitial lung process. The morbidity associated with CVID may be reduced by early diagnosis and adequate dosage of immunoglobulins to minimalize the occurrence and progression of lung damage.

Key words:
bronchiectasis - interstitial lung - fibrosis - antibody deficiency - common variable immunodeficiency - lung damage

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