Relapse in acute promyelocytic leukemia and the role of hematopoietic stem cell transplantation in the treatment of APL

Česká verzia

Authors: P. Žák ¹; Z. Kořístek ²
Authors place of work: II. interní klinika – oddělení klinické hematologie, Lékařská fakulta v Hradci Králové, Univerzita Karlova v Praze, přednosta prof. MUDr. Jaroslav Malý, CSc. ¹; Interní hematoonkologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jiří Vorlíček, CSc. ²
Published in the journal: Vnitř Lék 2008; 54(7-8): 751-756
Category: Review

Summary

The authors focused on relapses and transplantation treatment in APL. The incidence of relapses, their risk factors, and extramedullary relapses are reviewed. Considering treatment of relapses in APL, arsenic trioxide is now the standard treatment of APL relapse, however, treatment with gentuzumab ozogamicin should be considered when only a molecular relapse is detected. The following part of the issue is focused on the current status of hematopoietic stem cell transplantation in APL and on indications of transplantations from a modern APL therapy point of view.

Key words:
acute promyelocytic leukemia – relapse – extramedullary relapse – hematopoietic stem cell transplantation – arsenic trioxide – gentuzumab ozogamicin

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