Blood platelets metabolic and activation processes and options for their inhibition

Česká verzia

Authors: M. Pecka; J. Malý
Authors place of work: Oddělení klinické hematologie II. interní kliniky Lékařské fakulty UK a FN Hradec Králové, a Katedra interních oborů Lékařské fakulty UK Hradec Králové, přednosta prof. MUDr. Jaroslav Malý, CSc.
Published in the journal: Vnitř Lék 2009; 55(3): 263-266
Category: 15th Parizek's Days

Summary

A range of activation processes and confirmatory and metabolic changes take place in blood platelets following their activation. The paper discusses some of the blood platelet activation steps and describes the specific processes that take place on this level. Furthermore, the points at which it is possible to actively interfere with the blood platelet metabolism or activation processes are described. Antiplatelet treatment focuses on these points and there are efforts to identify active substances that either inhibit access to certain receptors or targets or, alternatively, inhibit the enzymes participating in these processes.

Key words:
blood platelet – activation – adhesion – aggregation – inhibition – blockade – antiplatelet treatment

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