AT₁-blockers in the treatment of hypertension

Česká verzia

Authors: J. Widimský jr.
Authors place of work: Centrum pro hypertenzi III. interní kliniky 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA
Published in the journal: Vnitř Lék 2009; 55(9): 841-844
Category: 80th Birthday - prof. MUDr. Miloš Štejfa, DrSc., FESC

Summary

Angiotensin receptor antagonists (AT₁-blockers) are considered as one of the major classes of antihypertensive drugs suitable for monotherapy as well as for combination treatment. Mechanisms of antihypertensive effects of AT₁-blockers are discussed altogether with the results of large clinical trials and indication in hypertension.

Key words:
AT₁-blockers – hypertension – treatment

Zdroje

1. Kaplan N. Clinical Hypertension. Philadelphia: Lippincott Williams & Wilkins 2006.

2. Healey JS, Baranchuk A, Crystal E et al. Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis. J Am Coll Cardiol 2005; 45: 1832–1839.

3. Cheng JW. Aliskiren: renin inhibitor for hypertension management. Clin Ther 2008; 30: 31–47.

4. Widimský J jr, Cífková R, Špinar J et al. Doporučení diagnostických a léčebných postupů u arteriální hypertenze – verze 2007. Doporučení České společnosti pro hypertenzi. Cor Vasa 2008; 50: K3–K16.

5. Weber MA. Angiotensin receptor blockers. In: Izzo JL, Sica DA, Black HR et al (eds). Hypertension primer. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins 2008: 461–464.

6. De Gasparo M, McInnes GT. Angiotensin receptor blockers. In: McInnes (ed). Clinical Pharmacology and Therapeutics of hypertension. Amsterdam: Elsevier 2008: 339–374.

7. Dahlhöf B, Devereux RB, Kjeldsen SE et al. LIFE study group. Cardiovascular morbidity and mortality in the Losartan intervention for End point reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002; 359: 995–1003.

8. Julius S, Kjeldsen SE, Weber M et al. VALUE trial group. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004; 363: 2022–2031.

9. Brenner BM, Cooper ME, de Zeeuw D et al. RENAAL Study. Effects of losartan on renal and cardiovascular outcomes in patients with type-2 diabetes and nephropathy. N Engl J Med 2001; 345: 861–869.

10. Pohl MA, Blumenthal S, Cordonnier DJ et al. Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: clinical implications and limitations. J Am Soc Nephrol 2005; 16: 3027–3037.

11. Parving HH, Lehnert H, Bröchner-Mortensen J et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001; 345: 870–878.

12. Schrader J, Lüders S, Kulschewski A et al. MOSES Study Group. Morbidity and Mortality After Stroke. Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES). Stroke 2005; 36: 1218–1226.

13. Lithell H, Hansson L, Skoog I et al. SCOPE Study Group. The Study on Cogni-tion and Prognosis in the Elderly (SCOPE). Principal results of a randomized double--blind intervention trial. J Hypertens 2003; 21: 875–886.

14. Yusuf S, Teo KK, Pogue J et al. ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008; 358: 1547–1559.

15. Conlin PR, Spence JD, Wiliams B et al. Angiotensin II antagonists for hypertension: are there differences in efficacy? Am J Hypertens 2000; 13: 418–426.

16. Fabia MJ, Abdilla N, Oltra R et al. Antihypertensive activity of angiotensin II AT₁ receptor antagonists: a systematic review of studies with 24 h ambulatory blood pressure monitoring. J Hypertens 2007; 25: 1327–1336.

17. Krupička J, Ceypová K, Kristenová P et al. Bezpečnost dlouhodobého podávání losartanu v běžné klinické praxi: neintervenční studie NCT-CZ 14/04/LOZ. Vnitř Lék 2008; 54: 1031–1038.