Paedi atric tumo urs metastasizing to bone marrow and their haematological characterisati on
Authors:
S. Valníček 1; J. Zapletal 1; J. Blatný 1; B. Jordanová 1; M. Kokeszová 1; D. Kodýtková 2
Authors place of work:
Oddělení klinické hematologi e FN Brno, pracoviště Bohunice, přednosta prof. MU Dr. Miroslav Penka, CSc., pracoviště Dětská nemocnice, vedo ucí lékař MU Dr. Jan Blatný, Ph. D.
1; Klinika dětské onkologi e Lékařské fakulty MU a FN Brno, pracoviště Dětská nemocnice, přednosta prof. MU Dr. Jaroslav Štěrba, Ph. D.
2
Published in the journal:
Vnitř Lék 2009; 55(Suppl 1)(Supplementum 1): 52-58
Summary
The paper provides an overvi ew of paedi atric tumo urs most frequently metastasizing to bone marrow, revi ews bri efly possible clinical and laboratory signs of metastases and lists and evalu ates morphological methods of their di agnosis with particular focus on haematological investigati ons of bone marrow aspirati ons. The paper bri efly to uches upon the morphology of the most important tumo urs in this gro up and, in attachments, presents their microphotographs with explanatory notes. Possible difficulti es faced by the clinici ans when evalu ating the tumo urs are highlighted. The a uthors cite published literature and share experi ences from their own practice.
Key words:
paedi atric tumo urs – bone marrow metastases – morphology – bone marrow aspirati on
Zdroje
1. Bain BJ, Clark DM, Lampert IA et al. Bone Marrow Pathology. Oxford: Blackwell Sci ence 2001; 430– 447, 456– 457.
2. Finkelstein JZ, Ekert H, Isaacs H et al. Bone marrow metastases in children with solid tumo urs. Am J Dis Child 1970; 119: 49– 52.
3. Delta BG, Pinkel D. Bone marrow aspirati on in children with malignant tumo urs. J Paedi atr 1964; 64: 542– 546.
4. Kleinschmid- Demasters BK. Bone marrow metastases from gli oblastoma multiforme. Cum Pathol 1997; 27: 197– 202.
5. Hoffmann M, Heinrich D, Dingeldein Det al. Medulloblastoma with oste oblastic metastasis and bone marrow fibrosis. Bone Marrow Transplant 1999; 23: 631.
6. Suprun H, Ryvlin AM. Metastatic carcinoma in histologic secti ons of aspirated bone marrow: a comparative a utopsy study. So uth Med J 1976; 69: 438– 439.
7. Savage RA, Hoffman GC, Shaker K. Di agnostic problems involved in detecti on of metastatic ne oplasms by bone marrow aspirate compared with needel bi opsy. Am J Clin Pathol 1978; 70: 623– 627.
8. Singh G, Kra use JR, Breitfeld V. Bone marrow examinati on for metasatatic tumo ur. Cancer 1977; 40: 2317– 2321.
9. Che ung NKV, Heller G, Kushner BH et al. Detecti on of metastatic ne uroblastoma in bone marrow: when is ro utine marrow histology insensitive? J Clin Oncol 1997; 15: 2807– 217.
10. Mufti GJ, Flandrin G, Schaefer HE et al. Atlas of malignant haematology London: Martin Dunitz Ltd. Reprint 1997; 356, 366– 368.
11. Toretzky JA, Kalebic T, Blahasley V et al. The insulin like growth factor- 1 receptor is required for EWS/ FLI- 1 transformati on o fibroblasts. J Bi ol Chem 1997; 272: 30822– 30827.
12. Franklin IM, Pritchard J. Detecti on of bone marrow invasi on by ne uroblastoma is improved by sampling at two sites with aspirates and bi opsi es. J Clin Pathol 1983; 36: 1215– 1218.
13. Reid MM. Detecti on of bone marrow infiltrati on by ne uroblastoma in clinical practice: how far have we come? Eur J Cancer A Gen Top 1994; 30: 134– 135.
14. Kačírková P, Campr V. Hematologický atlas krve a kostní dřeně. Praha: Grada 2007; 251– 252.
15. Gi angaspero F, Bigner SH, Kleihues P et al. Medulloblastoma. In: Kleihues P, Cavenee WK World He alth Organisati on Classificati on of Tumo urs. Pathology & Genetics Tumo urs of the Nervo us System. Oxord University Press, IARC Press, Lyon 2000; 6– 7, 129, 141, 153.
16. Reid MM, Sa unders PWG, Bown N et al. Alve olar rhabdomyosarcoma infiltrating bone marrow at presentati on: the value to di agnosis of bone marrow trephine bi opsy specimens. J Clin Pathol 1992; 45: 759– 762.
17. Rogers DW, Trele avan JG, Kemshe ad JT et al. Monoclonal antibodi es for detecting bone marrow invasi on by ne uroblastoma. J Clin Pathol 1989; 42: 422– 426.
18. Carey PJ, Thomas I, Buckle G et al. Immunocytochemical examinati on of bone marrow in disseminated ne uroblastoma. J Clin Pathol 1999; 43: 9– 12.
19. Salisbury J, Byers P. The staging of ne oplasi a. In: Salisbury J, Wo ods C, Byers P(eds). Dise ases of Bones and Jo ints: Cell Bi ology, Mechanisms, Pathology. London: Chapmann and Hall 1994.
20. Collins RD, Swerdlow SH. Pedi atric Hematopathology. New York, Edinburgh, London, Philadelphi a: Churchill Livingstone 2001; 18, 162.
Štítky
Diabetology Endocrinology Internal medicineČlánok vyšiel v časopise
Internal Medicine
2009 Číslo Supplementum 1
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