Current options for the treatment of osteoporosis

Česká verzia

Authors: V. Vyskočil
Authors place of work: Osteocentrum FN Plzeň, II. interní kliniky LF UK a FN Plzeň, přednosta prof. MUDr. Jan Filipovský, CSc., a Traumacentra Kliniky ortopedie a traumatologie pohybového ústrojí, přednosta prof. MUDr. Karel Koudela, CSc.
Published in the journal: Vnitř Lék 2010; 56(7): 749-758
Category: 80th Birthday - Jaroslava Blahoše, MD, DrSc.

Summary

The primary aim of osteoporosis treatment is prevention of osteoporotic fractures. The main factors in the development of these fractures are mechanic resistance of the bone and the bone quality. The importance of risk factor identification increases and it is important to consider the structural analysis of the hip-bone when evaluating and deciding whether to prescribe antiresorptive or osteoanabolic drugs or whether to just modify calcium and vitamin D intake. Various options are currently available for the pharmacological treatment of osteoporosis: calcium and vitamin D supplementation together with aminobisphosphonates, or osteoanabolic treatment with parathormone derivatives; monoclonal antibody to RANKL denosumab will also soon become available.

Key words:
osteoporosis – BMD – risk of fractures – FRAX – DXA – HAS software – calcium – vitamin D – alendronate – risedronate – ibandronate – zoledronate – calcitonin – strontium ranelate – parathormone derivatives – denosumab

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