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Is there a genetic determination of the age of type 2 diabetes mellitus diagnosis? Revised concept of the „thrifty genotype“ – editorial.


Authors: K. Kaňková
Authors place of work: Ústav patologické fyziologie Lékařské fakulty MU Brno, přednostka prof. MUDr. Anna Vašků, CSc.
Published in the journal: Vnitř Lék 2011; 57(2): 132-134
Category: Editorials


Zdroje

1. Florez JC, Hirschhorn J, Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet 2003; 4: 257–291.

2. Gloyn AL. The search for type 2 diabetes genes. Ageing Res Rev 2003; 2: 111–127.

3. Voight BF, Scott LJ, Steinthorsdottir V et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet; 2008; 42: 579–589.

4. Staiger H, Machicao F, Fritsche A et al. Pathomechanisms of type 2 diabetes genes. Endocr Rev 2009; 30: 557–585.

5. Zeggini E, McCarthy MI. TCF7L2: the biggest story in diabetes genetics since HLA? Diabetologia 2007; 50: 1–4.

6. McCarthy MI, Zeggini E. Genome-wide association studies in type 2 diabetes. Curr Diab Rep 2009; 9: 164–171.

7. Durbin RM, Abecasis GR, Altshuler DL et al. A map of human genome variation from population-scale sequencing. Nature 2009; 467: 1061–1073.

8. Ruchat SM, Elks CE, Loos RJ et al. Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies. Acta Diabetol 2009; 46: 217–226.

9. Cauchi S, Meyre D, Dina C et al. Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 2006; 55: 2903–2908.

10. Lehman DM, Hunt KJ, Leach RJ et al. Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans. Diabetes 2007; 56: 389–393.

11. Kimber CH, Doney AS, Pearson ER et al. TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels. Dia­betologia 2007; 50: 1186–1191.

Štítky
Diabetology Endocrinology Internal medicine

Článok vyšiel v časopise

Internal Medicine

Číslo 2

2011 Číslo 2
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