Food intake regulation – 2^nd part

Česká verzia

Authors: Ludmila Brunerová; Michal Anděl
Authors place of work: Centrum pro výzkum diabetu, metabolismu a výživy a Diabetologické centrum II. interní kliniky 3. LF UK a FN Královské Vinohrady, Praha, přednosta prof. MUDr. Michal Anděl, CSc.
Published in the journal: Vnitř Lék 2014; 60(1): 38-50
Category: Reviews

Summary

The review article summarizes the principles of hedonic regulation of food intake which represents the food intake independent on the maintenance of homeostasis. The theory describing hedonic regulation, so called Incentive Salience Theory, comprises three major processes: liking (positive attribution to food stimulus), wanting (motivation to gain it) and learning (identification of these stimuli and distinguishing them from those connected with aversive reaction). Neuronal reward circuits are the anatomical and functional substrates of hedonic regulation. They react to gustatory and olfactory (or visual) stimuli associated with food intake. A food item is preferred in case its consumption is connected with a pleasant feeling thus promoting the behavioural reaction. The probability of this reaction after repetitive exposure to such a stimulus is increased (learned preference). On the contrary, learned aversion after repetitive exposure is connected with avoidance of a food item associated with a negative feeling. Main mediators of hedonic regulation are endocannabinoids, opioids and monoamines (dopamine, serotonin). Dopamine in dorsal striatum via D2 receptors generates food motivation as a key means of survival, however in ventral striatum (nucleus accumbens) is responsible for motivation to food bringing pleasure. Serotonin via its receptors 5-HT1_A a T-HT2_C decreases intake of palatable food. It plays a significant role in the pathogenesis of eating disorders, particularly mental anorexia. There, a food restriction represents a kind of automedication to constitutionally pathologically increased serotonin levels. Detailed understanding of processes regulating food intake is a key to new pharmacological interventions in eating disorders.

Key words:
dopamine – endocannabinoids – hedonic regulation – opioids – reward circuits – serotonin

Zdroje

1. Alger SA, Schwalberg MD, Bigaouette JM et al. Effect of a tricyclic antidepressant and opiate antagonist on binge-eating behavior in normoweight bulimic and obese, binge-eating subjects. Am J Cli Nutr 1991; 53(4): 865–871.

2. Anderzhanova E, Covasa M, Hajnal A. Altered basal and stimulated accumbens dopamine release in obese OLETF rats as a function of age and diabetic status. Am J Physiol Regul Integr Comp Physiol 2007; 293(2): 603–611.

3. Aston-Jones C, Smith RJ, Sartor GC et al. Lateral hypothalamic orexín/hypocretin neurons: A role in reward-seeking and addiction. Brain Res 2010; 1314: 74–90.

4. Barnes MJ, Holmes G, Primeaux SD et al. Increased expression of mu opioid receptors in animals susceptible to diet-induced obesity. Peptides 2006; 27(12): 3292–3298.

5. Berridge KC, Robinson TE. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 1998; 28(3): 309–369.

6. Berridge KC. Food reward: brain substrates of wanting and liking. Neurosci Biobehav Rev 1996: 20(1): 1–25.

7. Berridge KC. Modulation of taste affect by hunger, caloric satiety, and sensory-specific satiety in the rat. Appetite 1991; 16(2):103–120.

8. Blum K, Braverman ER, Wood RC et al. Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report. Pharmacogenetics 1996; 6(4): 297–305.

9. Brunerová L, Potočková J, Horáček J et al. Central dopaminergic activity influences metabolic parameters in healthy men. Neuroendocrinology 2013; 97(2): 132–138.

10. Brunerová L, Anděl M. Regulace příjmu potravy – I. část. DMEV 2013; 16(1): 15–23.

11. Buck LB. Smell and taste: The chemical senses. Dostupné z WWW: <http://www.weizmann.ac.il/neurobiology/labs/ulanovsky/sites/neurobiology.labs.ulanovsky/files/uploads/kandel_ch32_smell_taste.pdf>.

12. Cameron JD, Riou ME, Tesson F et al. The TaqIA RFLP is associated with attenuated intervention-induced body weight loss and increased carbohydrate intake in post-menopausal obese women. Appetite 2013; 60(1): 111–116.

13. Compan V, Laurent L, Jean A et al. Serotonin signaling in eating disorders. WIREs Membr Transp Signal 2012; 1(6): 715–729.

14. Cooper SJ, Turkish S. Effects of naltrexone on food preference and concurrent behavioral responses in food-deprived rats. Pharmacol Biochem Behav 1989; 33(1): 17–20.

15. Cordeira JW, Frank L, Sena-Esteves M et al. Brain-derived neurotrophic factor regulates hedonic feeding by acting on the mesolimbic dopamine system. J Neurosci 2010; 30(7): 2533–2541.

16. Čihák R et al. Anatomie 3. Grada Publishing: Praha 2004. ISBN 978–80–247–1132–4.

17. Dela Cruz JAD, Icaza-Cukali D, Tayabali H et al. Roles of dopamine D1 and D2 receptors in the acquisition and express on of fat-conditioned flavor preferences in rats. Neurobiol Learn Mem 2012; 97(3): 332–331.

18. Di Marzo V, Matias I. Endocannabinoid control of food intake and energy balance. Nat Neurosci 2005; 8(5): 585–589.

19. Dickson SL, Egecioglu E, Landgren S et al. The role of the central ghrelin system in reward from food and chemical drugs. Mol Cell Endocrinol 2011; 340(1): 80–87.

20. Egecioglu E, Skibicka KP, Hansson C et al. Hedonic and incentive signal for body weight control. Rev Endocr Metab Disord 2011; 12(3): 141–151.

21. Finlayson G, King N, Blundell JE. Liking vs. wanting food: importance for human appetite control and weight regulation. Neurosci Biobehav Rev 2007; 31(7): 987–1002.

22. Geiger BM, Haburcak M, Avena NM et al. Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity. Neuroscience 2009; 159(4): 1193–1199.

23. Horáček J, Bubeníková-Valešová V, Kopeček M et al. Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia. CNS Drugs 2006; 20(5): 389–409.

24. Christopoulou FD, Kiortsis DN. An overview of the metabolic effects of nimonabant in randomized controlled trials: potential for other cannabinoid 1 receptor blockers in obesity. J Clin Pharm Ther 2011; 36(1): 10–18.

25. Joranby L, Pineda KF, Gold MS. Addiction to Food and Brain Reward Systems. Sexual Addic Compulsivity 2005; 12(2–3): 201–217.

26. Kaye WH, Barbarich NC, Putnam K et al. Anxiolytic effects of acute tryptophan depletion in anorexia nervosa. Int J Eat Disord 2003; 33(3): 257–267.

27. Kaye WH, Fudge JL, Paulus M. New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neunosci 2009; 10(8): 573–584.

28. Koukolík F. Lidský mozek. Funkční systémy. Norma a poruchy. 3. ed. Galén: Praha 2011. ISBN: 978–80–7262–771–4.

29. Lam DD, Garfield AS, Marston OJ et al. Brain serotonin system in the coordination of food intake and body weight. Pharmacol Biochem Behav 2010; 97(1): 84–91.

30. Luo S, Luo J, Meíer AH et al. Dopaminergic neurotoxin administration to the area of the suprachiasmatic nuclei induces insulin resistance. Neuroreport 1997; 8(16): 3495–3499.

31. Magalhães CP, de Freitas MF, Noqueira MI et al. Modulatory role of serotonin on feeding behavior. Nutr Neurosci 2010; 13(6): 246–255.

32. McFarland K, Ettenberg A. Haloperidol does not affect motivational processes in an operant runway model of food-seeking bebavior. Behav Neurosci 1998; 112(3): 630–635.

33. Mitchell JE, Morley JE, Levine AS et al. High-dose naltrexone therapy and dietary counseling for obesity. Biol Psychiatry 1987; 22(1): 35–42.

34. Nathan PJ, Bullmore ET. From taste hedonics to motivational drive: central µ-opioid receptors and binge-eating behaviour. Int J Neuropsychopharmacol 2009; 12(7): 995–1008.

35. Pijl H, Ohashi S, Matsuda M et al. Bromocriptine: a novel approach to the treatment of type 2 diabetes. Diabetes Care 2000; 23(8): 1154–1161.

36. Pijl H. Reduced dopaminergic tone in hypothalamic neural circuits: expression of a “thrifty” genotype underlying the metabolic syndrome? Eur J Pharmacol 2003; 480(1–3): 125–131.

37. Pratt WE, Blackstone K. Nucleus accumbens acetylcholine and food intake: decreased muscarinic tone reduces feeding but not food-seeking. Behav Brain Res 2009; 198(1): 252–257.

38. Ravinet Trillou C, Delgorge C, Menet C et al. CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. Int J Obes Relat Metab Disord 2004; 28(4): 640–648.

39. Sclafani A, Touzani K, Bodnar RJ. Dopamine and learned fond preferences. Physiol Behav 2011; 104(1): 64–68.

40. Schreiber R, De Vry J. Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Prog Neuropsychopharmacol Biol Psychiatry 2002; 26(3): 441–449.

41. Schwartz MW, Woods SC, Porte D jr. et al. Central nervous system control of food intake. Nature 2000; 404(6778): 661–671.

42. Small DM, Jones-Gotman M, Dagher A. Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. Neuroimage 2003; 19(4): 1709–1715.

43. Smith KS, Berridge KC. Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. J Neurosci 2007; 27(7): 1594–1605.

44. Steiger H. Eating disorders and the serotonin connection: state, trait and developmental effects. J Psychiatry Neurosci 2004; 29(1): 20–29.

45. Stice E, Yokum S, Blum K et al. Weight gain is associated with reduced striatal response to palatable food. J Neurosci 2010; 30(39): 13105–13109.

46. Szczypka MS, Kwok K, Brot MD et al. Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron 2001; 30(3): 819–828.

47. Taha SA. Preference or fat? Revisiting opioid effects on food intake. Physiol Behav 2010; 100(5): 429–437.

48. Tracy AL, Jarrard LE, Davidson TL. The hippocampus and motivation revisited: appetite and activity. Behav Brain Res 2001; 127(1–2): 13–23.

49. Uher R, Papežová H. Mozkové faktory u poruch příjmu potravy. In: Papežová H (ed.) Spektrum poruch příjmu potravy. Grada Publishing: Praha 2010. ISBN 8024724251.

50. Vicentic A, Jones DC The CART (cocaine- and amphetamine-regulated transcript) system in appetite and drug addiction. J Pharmacol Exp Ther 2007; 320(2): 499–506.

51. Volkow ND, Wang GJ, Fowler JS et al. ,,Nonhedonic“ food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect. Synapse 2002; 44(3): 175–180.

52. Volkow ND, Wang GJ, Baler RD Reward, dopamine and the control of food intake: implications for obesity. Trends Cong Sci 2011; 15(1): 37–46.

53. Wang GJ, Volkow ND, Thanos PK et al. Imaging of brain dopamine pathways: implications for understanding obesity. J Addict Med 2009; 3(1): 8–18.

54. Wang GJ, Volkow ND, Fowler JS. The role of dopamine in motivation for food in humans: implication for obesity. Expert Opin Ther Targets 2002; 6(5): 601–609.

55. Wurtman RJ, Wurtman JJ. Carbohydrate craving, obesity and brain serotonin. Appetite 1986; 7(Suppl): 99–103.

56. Wurtman RJ, Wurtman JJ, Regan MM et al. Effects of normal meals rich in carbohydrates or proteins on plasma tryptophan and tyrosine ratios. Am J Clin Nutr 2003; 77(1): 128–132.

57. Yyanik T, Dominiquez G, Kuhar MJ et al. The Leu34Phe ProCART mutation leads to cocain- and amphetamine-regulated transcript (CART) deficiency: a possible cause for obesity in humans. Endocrinology 2006; 147(1): 39–43.