Fecal microbiota transplantation

Česká verzia

Authors: Igor Šturdík; Tibor Hlavatý; Juraj Payer
Authors place of work: V. interná klinika LF UK a UN Bratislava, pracovisko Nemocnica Ružinov, Slovenská republika
Published in the journal: Vnitř Lék 2016; 62(2): 147-151
Category: Reviews

Summary

Fecal microbiota transplantation (FMT) is a therapeutic method, in which the fecal microflora from healthy donors is transmitted to the patient to restore the healthy microbial composition of the gut. In the recent years, there is a growing interest in the therapeutic potential of FMT in various diseases. The standard FMT protocols do not exist. Procedures of FMT vary in several aspects such as donor selection, preparation of fecal material, preparation of the recipient and administration way. FMT appears to be the most successful in the treatment of recurrent Clostridium difficile infection (CDI), randomized controlled studies reported 90 % success rate. There is a limited evidence for FMT as a treatment of ulcerative colitis. FMT has been also studied as treatment of diseases with impaired gut microbiota, such as cardiovascular, autoimmune and metabolic diseases. Many unanswered questions with regard to FMT remain and further research is needed.

Key words:
Clostridium difficile – fecal microbiota transplantation – gut microbiota – inflammatory bowel diseases

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