Adiponectin in patients with metabolic syndrome and diseases of the liver, bile ducts and pancreas

Česká verzia

Authors: Adam Vašura ; Martin Blaho; Petr Dítě; Tomáš Kupka; Pavel Svoboda; Arnošt Martínek
Authors place of work: Gastroenterologické oddělení Interní kliniky LF OU a FN Ostrava
Published in the journal: Vnitř Lék 2017; 63(12): 945-948
Category: Reviews

Summary

Epidemiological data show that the metabolic syndrome can be diagnosed in up to 30 % of the population. Regarding 5 components of the metabolic syndrome, three of them, in case of positivity (visceral obesity, arterial hypertension, hypertriglyceridemia, changes of HDL-cholesterol levels and type 2 diabetes mellitus), are pathogenic factors which are the most frequently related to cardiovascular diseases, but currently they are also the focus of interest for gastroenterologists. The relationship between non-alcoholic hepatic steatosis, including non-alcoholic steatohepatitis, has been described. Less is known so far about the relation to the pancreas disease, particularly with respect to the status referred to as non-alcoholic fatty pancreas disease. The hormone selectively produced by adipose tissue is adiponectin. This protein is studied as a possible biomarker in people with metabolic syndrome, including obesity. Besides that, there is a question studied whether adiponectin can also play a significant role in the pathogenesis of diseases associated with fat building up in parenchymatous organs. Finding a reliable biomarker for patients with metabolic syndrome or diseases of the liver, biliary system and pancreas in relation to metabolic syndrome, presents a big challenge. And adiponectin is one of the promising biomarkers.

Key words:
adiponectin – biliary disease – metabolic syndrome – pancreatic steatosis – steatohepatitis

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