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preLekára.sk / Journals / Internal Medicine / 2018 - 6

Conventional and biological therapy for inflammatory bowel disease

Česká verzia

Authors: Martin Bortlík 1,2,3
Authors place of work: Klinické a výzkumné centrum pro střevní záněty, ISCARE I. V. F. a. s., Praha 1;  Interní klinika 1. LF UK a ÚVN – Vojenské fakultní nemocnice Praha 2;  Farmakologický ústav 1. LF UK a VFN v Praze 3
Published in the journal: Vnitř Lék 2018; 64(6): 642-653
Category: Reviews

Summary

Crohn’s disease and ulcerative colitis are chronic digestive conditions incurable by medication or surgery, which affect mainly young populations in economically developed countries. A medical treatment includes conventional preparations: aminosalicylates, corticosteroids, immunosuppressive drugs, antibiotics and exceptionally also probiotics, while in not responding patients or those at higher risk of an adverse course a biological treatment is indicated. The most frequently administered biologics are antibodies directed against the tumour-necrosis factor α, which are highly effective, but the length of their application is limited by a loss of efficiency and incidence of adverse effects. The new, more selectively acting biologics include anti-integrin antibodies and interleukin 12/23 antibodies.

Key words:

biological treatment – Crohn’s disease – idiopathic bowel inflammation – medication-based treat­ment – ulcerative colitis

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Článek Celiac disease in 2018
Článek Diagnosis of gastrointestinal motility disorders
Článek Diverticular disease: diagnosis and treatment
Článek Familial adenomatous polyposis: complex patient management
Článek The IBD outpatient care in the clinical practice
Článek PSC-IBD: specific phenotype of inflammatory bowel disease associated with primary sclerosing cholangitis
Článek Possibilities of therapeutic manipulation of the gut microbiota
Článek Prokinetics and their use in gastroenterology
Článek Colorectal cancer screening
Článek Therapeutic digestive endoscopy I
Článek Therapeutic digestive endoscopy II
Článok vyšiel v časopise

Internal Medicine

Číslo 6
2018 Číslo 6
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