IL-1 family cytokines in chronic inflammatory disorders

Česká verzia

Authors: Ilja Stříž
Authors place of work: Pracoviště klinické a transplantační imunologie IKEM, Praha
Published in the journal: Vnitř Lék 2019; 65(2): 81-85
Category:

Summary

IL-1 family represent a group of structurally related cytokines with prevailing pro-inflammatory (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β a IL-37γ) or anti-inflammatory (IL-1Ra, IL-36Ra, IL-38, IL-37) effects. They are involved not only in defense mechanisms and physiological modulation of homeostatic processes, but also in the imunopathogenesis of many diseases including rheumatoid arthritis, inflammatory bowel disease, autoimmune and auto-inflammatory diseases. Recently, advances in biologic therapy enabled blocking of IL-1α, IL-1β, IL-18, and IL-33 with new monoclonal antibodies, soluble receptors, or recombinant binding proteins.

Keywords:

Cytokines – inflammation – interleukin 1

Zdroje

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