Pancytopenia as the main manifestation of human immunodeficiency virus infection in the AIDS stage The authors present a case
Authors:
Pavel Polák 1,2,3,4; Leoš Křen 2,4,5; Jana Lindušková 6; Andrea Pavlíková 7; Michael Doubek 3,4; Markéta Šejnohová 3; Miroslav Penka 1,2,3,4
Authors place of work:
Oddělení klinické hematologie, Fakultní nemocnice Brno
1; Katedra laboratorních metod, Fakultní nemocnice Brno
2; Interní hematologická a onkologická klinika, Fakultní nemocnice Brno
3; Lékařská fakulta Masarykovy univerzity Brno
4; Ústav patologie, Fakultní nemocnice Brno
5; Oddělení klinické mikrobiologie a imunologie, Fakultní nemocnice Brno
6; Národní referenční laboratoř pro HIV/AIDS, Státní zdravotní ústav, Praha
7
Published in the journal:
Vnitř Lék 2021; 67(E-4): 26-28
Category:
Case Report
Summary
The authors present a case report of 59-years-old woman examined for pancytopenia recently diagnosed during hospitalization for bilateral interstitial pneumonia without any confirmed etiological agents. Concomitantly, some systemic symptoms like lack of appetite and weight loss were present. Primary hematological disease was ruled out. Positivity of serological screening for HIV-1,2 was rather surprising. Absolute count of CD4+ lymphocytes was 8/μl. Thus, HIV infection was already in stage of AIDS and retrospectively, the interstitial pneumonia has to be judged as AIDS-indicative illness.
Keywords:
pancytopenia – HIV – interstitial pneumonia
Zdroje
1. Beneš J et al. Infekční nemoci. 1st Ed. Praha, Galén, 2009: 651s. ISBN 978–80–7262–644–1.
2. Penka M et al. Neonkologická hematologie. 2. vydání. Praha, Grada, 2009: 240s. ISBN 978–80–247–2299–3.
3. http://szu.cz/uploads/documents/CeM/HIV_AIDS/rocni_zpravy/2019/Grafy_k_ tiskove_zprave_NRL_pro_HIV_AIDS_Trendy_vyvoje_a_vyskyt_HIV_AIDS_v_CR_v_ roce_2019.pdf.
4. European Centre for Disease Prevention and Control, WHO Regional Office for Europe. HIV/AIDS surveillance in Europe 2019 – 2018 data. Stockholm: ECDC; 2019. Dostupné z: https://www.ecdc.europa.eu/en/publications-data/hivaids-surveillance-europe- -2019–2018-data.
5. Maier KP. Hepatitis-Hepatitisfolgen. 6. Aufl., Bern, Verlag Hans Huber, 2010: 457 s., pages 135–211. ISBN 978–3-456–84674–3.
6. Zákon O ochraně veřejného zdraví č. 258 Sb. 2000.
7. Chrdle A, Skurák M, Fránová D. Kdy, koho a jak testovat na infekci HIV? Jednoduchý postup při testování v primární péči a odborných ambulancích. Practicus 2019; 18(9): 14–22.
8. Genet P, Sutton L, Chaoui D et al. Prevalence of monoclonal gammopathy in HIV patients in 2014. J Int AIDS Soc 2014; 17(4 Suppl 3): 19649. doi: 10.7448/IAS.17.4.19649. eCollection 2014.
9. Jou E, Gligich O, Chan AC et al. Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients. Hematol Oncol 2017; 35(1): 64–68. doi: 10.1002/hon.2247. Epub 2015 Jul 24.
10. Jou E, Gligich O, Chan ACY et al. Viral co-infections and paraproteins in HIV: effect on development of hematological malignancies. Ann Hematol 2016; 95(4): 575–580. doi: 10.1007/s00277–016–2588-z.
Štítky
Diabetology Endocrinology Internal medicineČlánok vyšiel v časopise
Internal Medicine
2021 Číslo E-4
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