Acute kidney injury due to antimicrobial therapy

Česká verzia

Authors: Viktor Klementa ¹; Naděžda Petejová ²; Josef Zadražil ¹; Pavel Horák ¹; Jitka Prošková ³; Olga Klementová ⁴
Authors place of work: III. interní klinika – nefrologická, revmatologická a endokrinologická LF UP a FN Olomouc ¹; Interní a kardiologická klinika LF a FN Ostrava ²; oddělení klinické biochemie FN Olomouc ³; Klinika anesteziologie, resuscitace a intenzivní medicíny LF UP a FN Olomouc ⁴
Published in the journal: Vnitř Lék 2022; 68(4): 227-233
Category: Review Articles

Summary

One of the common causes of acute kidney injury (AKI) is drug nephrotoxicity. A large group of drugs associated with AKI includes a considerable number of antimicrobials. Clinical manifestations range from mild forms of tubular damage to significant deterioration of renal function requiring renal replacement therapy. Several mechanisms have been described, although the most common are acute interstitial nephritis, acute tubular necrosis, crystalic nephropathy or proximal/distal tubulopathy with electrolyte abnormalities. General risk factors for antimicrobial-induced AKI include pre-existing chronic kidney disease and concomitant use of drugs with nephrotoxic potential. Prevention and early recognition of AKI are the standard approach to mitigate AKI and avoid morbidity.

Keywords:

Vancomycin – antibiotics – acute kidney injury – aminoglycosides

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