Histamine intolerance

Česká verzia

Authors: Roman Hakl; Jiří Litzman
Authors place of work: Ústav klinické imunologie a alergologie, Fakultní nemocnice u sv. Anny v Brně, Lékařská fakulta, Masarykova, univerzita, Brno
Published in the journal: Vnitř Lék 2023; 69(1): 37-40
Category: Review Articles
doi: https://doi.org/10.36290/vnl.2023.005

Summary

Histamine intolerance (HIT) is a non-immunological disorder associated with an impaired ability to metabolize ingested histamine. Manifestation of HIT includes gastrointestinal and non-gastrointestinal symptoms. Clinical symptoms of HIT are non-specific and can imitate different diseases such as allergies, food intolerance, mastocytosis and other. The diagnosis of HIT is difficult. There are several candidate tests to detect DAO insufficiency, but their informative value is questionable. Currently, a positive clinical effect of a low-histamine diet is the most important for establishing the diagnosis. Equally in the treatment, a low-histamine diet is the most crucial approach. Other therapeutic options such as DAO supplementation treatment with antihistamines or probiotics are considered as complementary treatments. Our article provides a review on histamine intolerance, focusing on etiology and the diagnostic and treatment possibilities.

Keywords:

histamine intolerance – diamine oxidase (DAO) – histamine intoxication

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