Psychiatric Problems in the Internal Praxis. Part II.
PSYCHIATRICKÁ PROBLEMATIKA V INTERNÍ PRAXIII. Část
Druhá generace antipsychotik (= atypická antipsychotika) má řadu výhod hlavně z hlediska nízké afinity k extrapyramidovém systému. Jejich podávání však může vést k vedlejším účinkům, které mohou být problematické hlavně z pohledu interního lékaře. Je to zejména přírůstek hmotnosti a s tímto částečně související narušení lipidového a glukózového metabolizmu. V neposlední řadě některá atypická antipsychotika vedou k prodloužení QT intervalu se všemi dalšími možnými důsledky.
Klíčová slova:
antipsychotika, extrapyramidový systém, hmotnost, obezita, dopamin, diabetes mellitus, interval QT, komorové tachykardie.
Authors:
E. Češková
Authors‘ workplace:
Psychiatrická klinika LF MU a FN, Brno-Bohunice
Published in:
Čas. Lék. čes. 2001; : 547-550
Category:
Overview
The second generation of antipsychotic drugs (= atypical antipsychotics) have several advantages namely their low affinity to the extrapyramidal system. However, the administration of these drugs may bring about some side effects, which are particularly significant for the internal praxis. They include the weight gain and related impairment of the lipid and glucose metabolism. Some atypical antipsychotics can cause prolongation of the QT interval with all possible consequences.
Key words:
antipsychotics, extrapyramidal system, body mass, obesity, dopamine, diabetes mellitus, QT interval, ventricular tachycardia.
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- Psychiatric Problems in the Internal Praxis. Part II.