New Approach to Cholesterol
NOVÝ POHLAD NA CHOLESTEROL
Hoci o hypercholesterolémii a s ňou spojených rizikách vzniku aterosklerózy je velké množstvo poznatkov, o zmenách v biosyntéze cholesterolu je známe ovefa menej. Situácia sa zmenila až po objave poruchy metabolizmu cholesterolu u malformačného Smithovho-Lemliho-Opitzovho syndrómu, ktorý sa tak stal modelovým ochorením na štúdium tejto problematiky. Cholesterol má mimoriadne dóležité funkcie v organizme. Napriek tomu neustále prevládajú doporučenia na znižovanie jeho sérovej hladiny, hoci nie sú známe následky, spojené s jeho nedostatkom. Cholesterol móžeme nad'alej považovat za záhadný metabolit s mnohými doposiaT neobjasnenými funkciami.
Klíčová slova:
biosyntéza cholesterolu, Smithov-Lemliho-Opitzov syndomm, esenciálne funkcie cholesterolu, ateroskleróza, morfogenéza.
Authors:
V. Bzdúch; D. Behúlová 1; I. Kajaba 2
Authors place of work:
I. detská klinika Detskej fakultnej nemocnice, Bratislava, SR IOddelenie klinickej biochémie Detskej fakultnej nemocnice, Bratislava, SR 2Ústav preventívnej a klinickej medicíny, Bratislava, SR
Published in the journal:
Čas. Lék. čes. 2001; : 685-687
Category:
Summary
Although much is known about hypercholesterolemia and the associated risk for the development of atherosclerosis, vety little research has focused on altered cholesterol biosynthesis. Recent discovery tkat the biochemical basis for the human malformation syndrome, Smith-Lemli-Opiu syndrome appears to lie in altered cholesterol biosynthesis has changed this situation. Cholesterol has an extraordinary important functions in organism. Recommendations to lower serum cholesterol are widespread, yet low serum cholesterol is associated with poorly understood morbidity. Cholesterol is still an enigmatic, essential metabolite and much remains to learn about it.
Key words:
cholesterol biosynthesis, Smith-Lemli-Opiu syndrome, essential function of cholesterol, atherosclerosis, morphogenesis.
Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
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