New Perspectives of Nuclear Receptors PPAR Modulation

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Nové perspektivy ovlivnění jadernýchreceptorů PPAR

Ovlivnění rodiny jaderných receptorů označovaná jako PPAR (receptory aktivované proliferátory peroxisomů) jejednou z nejperspektivnějších oblastí farmakoterapie. Běžně se dnes týká problematiky antidiabetik a hypolipidemik(PPAR gama a alfa receptorů). Velký rozvoj lze očekávat v oblasti ovlivnění tzv. PPAR beta receptorů a v oblastiléků ovlivňujících více receptorů najednou (double a triple senzitizéry). Farmaka působící na PPAR budou v budoucnostivyužívána také v oblasti dermatologie, obezitologie, onkologie, chirurgie, gastroenterologie a také neurologiea psychiatrie.

Klíčová slova:
diabetes, ateroskleróza, double senzitizéry, triple senzitizéry, hojení ran, onkologie, protizánětlivýefekt, neuropsychiatrie.

Authors: Š. Svačina
Authors‘ workplace: III. interní klinika 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 2004; : 731-733
Category:

Overview

Modulation of the function of nuclear receptors PPAR (peroxisome proliferators activated receptors) is one of mostattractive fields in pharmacological research. Today it represents an important part of the clinical use of antidiabeticand hypolipidemic drugs (PPAR alpha and gamma). Significant development is expected in PPAR beta modulationand in the complex intervention of several receptor families (double and triple sensitisers) Drugs influencing PPARwill be used in future in dermatology, surgery, obesitology, oncology, gastroenterology and also in neurology andpsychiatry

Key words:
diabetes, atherosclerosis, double sensitisers, triple sensitisers, wound healing, anti-inflammatory effect,neuropsychiatry.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

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