Thrombembolic Complications of Sepsis and Their Pharmacological Prophylaxis
Trombotické komplikace při sepsi a jejich farmakologická profylaxe
Pacienti s těžkou sepsí mají zvýšené riziko vzniku tromboembolických komplikací. Cílem tohoto článku je objasnit patogenezi koagulačních abnormalit při těžké sepsi a shrnout současné poznatky o vztahu mezi systémovou zánětlivou odpovědí organizmu a aktivací koagulace. Článek nabízí přehled o incidenci, rizikových faktorech a současných doporučeních pro profylaxi tromboembolické nemoci u pacientů se sepsí.
Klíčová slova:
sepse, zánět, žilní trombóza.
Authors:
Z. Zenáhlíková 1; J. Výborný 2; Z. Uchytil 2; Z. Krška 2; J. Mazoch 1; I. Malíková 1; J. Kvasnička 1
Authors‘ workplace:
Trombotické centrum a Centrální hematologické laboratoře VFN, Praha
1; 1. chirurgická klinika VFN, Praha
2
Published in:
Čas. Lék. čes. 2007; 146: 597-602
Category:
Review Article
Overview
Patients with severe sepsis are at increased risk for developing thrombembolic phenomena. This article aims to clarify the association between systemic inflammation activation and coagulation, pathogenesis of coagulation abnormalities during severe sepsis. The article reviews incidence and deep venous thrombosis risk factors among these patients and summarizes recent evidence-based guidelines for deep venous thrombosis prophylaxis.
Key words:
sepsis, inflammation, venous thromboembolism.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
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