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Differential Diagnosis of the Refractory Gastroesophageal Reflux Diseases


Authors: K. Lukáš;  A. Žák
Authors place of work: IV. interní klinika 1. LF UK a VFN, Praha
Published in the journal: Čas. Lék. čes. 2008; 147: 599-606
Category: Review Article

Summary

Refractory gastroesophageal reflux disease is a condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Despite bi-daily administration of proton pump inhibitors, reflux symptoms may persist, new symptoms may occur or become unmasked, and oesophagitis can fail to heal. Some of these patients do not take their medications, well-defined pharmacokinetic factors or genetic polymorphisms can contribute, nonacid reflux can be the culprit or their oesophagitis and/or symptoms may not be due to acid reflux. The first investigation to perform in the refractory gastroesophageal reflux disease is the upper endoscopy to exclude the possibility of refractory peptic ulcer disease or, less likely, cancer, and to identify „other“ oesophagitis (nonerosive alternative oesophagitis – microscopic oesophagitis).

Key words:
refractory gastroesophageal reflux disease, erosive oesophagitis, non-erosive oesophagitis, proton pump inhibitor.


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Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

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