Molecular biology and immunopathogenetic mechanisms of sepsis
Authors:
M. Průcha
Authors place of work:
Nemocnice Na Homolce Praha, Oddělení klinické biochemie, hematologie a imunologie
Published in the journal:
Čas. Lék. čes. 2009; 148: 86-90
Category:
Review Article
Summary
Sepsis, the systemic inflammatory response to infection, causes high mortality in patients in non-coronary units of intensive care. The most important characteristic of sepsis is the interaction between two subjects, the macro and the microorganism, associated with the dysfunction of innate and adaptive immunity. Sepsis is understood more as a dynamic syndrome characterized by many phenomenona which are often antagonistic. The inflammation, characterizing sepsis, does not act as a primary physiological compensatory mechanism and rather oscillates between the phase of hyperinflammatory response and anergy or immunoparalysis. The elucidation of the pathogenesis of sepsis is linked to the understanding of immunopathogenetic mechanisms, which characterize the interaction between the macro and microorganisms.
Key words:
sepsis, immunity, inflammation, apoptosis, immunogenetics.
Zdroje
1. Černý V, Novák I, Šrámek V. Prevalence těžké sepse v České republice – prospektivní multicentrická jednodenní studie. Anest Intenziv Med 2003; 14: 218–222.
2. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29: 1303–1310.
3. Dombrovskiy VY, Martin AA, Sunderram J, et al. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003. Crit Care Med 2007; 35: 1244–1250.
4. Dellinger RP. Cardiovascular management of septic shock. Crit Care Med 2003; 31: 946–955.
5. Esper A, Martin GS. Is severe sepsis increasing in incidence AND severity? Crit Care Med 2007; 35: 1414–1415.
6. Bone RC, Balk RA, Cerra FB, et al. American College of Chest Physicians/Society of Critical Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of Innovative therapies in sepsis. Chest 1992; 101: 1644–1655.
7. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2003; 29: 530–538.
8. Braude AE, Jones JL, Douglas H. The behavior of Escherichia coli endotoxin (somatic antigen) during infectious arthritis. J Immunol 1963; 90: 297–301.
9. Andriole VT. Urinary tract infections in the 90s: Pathogenesis and management. Infection 1992; 20(Suppl 4): S251–S256.
10. Feltis BA, Jechorek RP, Erlanden SL, et al. Bacterial translocation and lipopolysaccharide-induced mortality in genetically macrophage-deficient op/op mice. Shock 1994; 2: 29–33.
11. Go LL, Healey PJ, Watkins SC. et al. The effect of endotoxin on intestinal mucosal permeability to bacteria in vitro. Arch Surg 1995; 130: 53–58.
12. Sedman PC, MacFie J, Sagar P, et al. The prevalence of gut translocation in humans. Gastroenterology 1994; 107: 643–649.
13. Cabie A, Farkas JC, Fitting C, et al. High levels of portal TNF-α during abdominal aortic surgery in man. Cytokine 1993; 5: 448–453.
14. Owens WE, Berg RD. Bacterial translocation from the gastrointestinal tract of thymectomized mice. Curr Microbiol 1982; 7: 169–174.
15. O’Boyle CJ, Mac Fie J, Mitchell CJ, et al. Microbiology of bacterial translocation in humans. Gut 1998; 42: 29–35.
16. Morin M, Schindler R, Wakabayashi G, et al. Picogram concentrations of endotoxin stimulate synthesis of IL-1β and TNF‑α by human peripheral blood mononuclear cells exposed to recombinant human C5a. Eur Cytokine Netw 1991; 2: 27–30.
17. Quereshi ST, Lariviere G, Leveque S, et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4. J Exp Med 1999; 189: 615–625.
18. Cleveland MG, Gorham JD, Murphy TL, et al. Lipoteichoic acid preparations of Gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect Immun 1996; 64: 1906–1912.
19. Medzhitov R, Janeway C. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997; 91: 295–298.
20. Hemmi H. A Toll-like receptor recognizes bacterial DNA. Nature 2000; 408: 740–745.
21. Ozinsky A. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc Natl Acad Sci USA 2000; 97: 13766–13771.
22. Broad A, Kirby JA, Jones DEJ. Toll-like receptor interactions: tolerance of MyD88- dependent cytokines but enhancement of MyD88-independent interferon-ß production. Immunology 2007; 120: 103–111.
23. Wiel E, Lebuffe G, Vallet B. Bacterial CpG DNA in septic shock. In: Yearbook of Intensive Care and Emergency Medicine 2002; Ed. JL.Vincent: 388–398.
24. Schouten M, Wiersinga WJ, Levi M, van der Poll. Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol 2008; 83: 536–545.
25. Stief TW, Ijagha O, Weiste B, et al. Analysis of hemostasis alterations in sepsis. Blood Coagul Fibrinolysis 2007; 18: 179–186.
26. Průcha M, Herold I, Zazula R, Dubská L, Kavka B. Monocytární deaktivace a produkce tumor nekrotizujícího faktoru-α ex vivo prognostické parametry u pacientů jednotek intenzivní péče. Anesteziologie Intenzivní medicína 2003; 5: 223–228.
27. Calandra T, Echtenacher B, Le Roy D, et al. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nature Medicine 2000; 6: 164–170.
28. Wang H, Zhang M, et al. HMG-I as a late mediator of endotoxin letality in mice. Science 1999; 285: 248–251.
29. Oberholzer A, Oberholzer C, Moldawer LL. Interleukin-10: a complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug. Crit Care Med 2002; 30: S58–S63.
30. Ayala A, Lomas JL, Grutkoski PS, Chung CS. Pathological aspects of apoptosis in severe sepsis and shock? Int J Biochem & Cell Biol 2003; 35: 715–720.
31. Chung CS, Chaudry IH, Ayala A. The apoptotic response of the lymphoid immune system to trauma, shock and sepsis. In Vincent J-L, editor. Yearbook of Intensive Care and Emergency Medicine. Berlin: Springer Verlag 2000; 27–40.
32. Hotchkiss RS, Swanson PE, Knudson CM, Chang M, et al. Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 1999; 162: 4148–4156.
33. Wesche-Soldato DE, Stan RZ, Chung CHS, Ayala A. The apoptotic pathway as a therapeutic target in sepsis. Curr Drug Targets 2007; 8: 493–500.
34. Borowikova LV, Ivanova S, Zhang H, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405: 458–462.
35. Woiciechowsky C, Asadullah K, Nestler D, et al. Sympathetic activation trigger systemic IL-10 release in immunodepression induced by brain injury. Nat Med 1998; 4: 808–813.
36. Pellegrini JD, De Ak J, Kodys K, et al. Relationships between T lymphocytes apoptosis and anergy following trauma. J Surg Res 2000; 88: 200–206.
37. Greene DR, Beere HM. Apoptosis:gone but not forgotten. Nature 2000; 405: 28–29.
38. Fadok VA, Bratton DL, Rose DM, et al. A receptor for phosphatidylserine-specific clearence of apoptotic cells. Nature 2000; 405: 85–90.
39. Smirnova I, Mann N, Dois A, et al. Assay of locus–specific genetic load implicates rare Toll–like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci USA 2003; 100: 6075–6080.
40. Haralambous E, Hibberd ML, Hermans PWM, et al. Role of functional plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism in susceptibility, severity, and outcome of meningococcal disease in Caucasian children. Crit Care Med 2003; 31: 2788–2793.
Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
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