Matrix Gla protein as natural inhibitor of vascular calcification and potential treatment target

Česká verzia

Authors: doc. MUDr. CSc. Otto Mayer jr.
Authors place of work: Biomedicinské centrum LF UK Plzeň: E. Beneše ; II. interní klinika LF UK a FN Plzeň
Published in the journal: Čas. Lék. čes. 2016; 155: 179-182
Category: Review Article

Summary

Vascular calcification was once regarded as an advanced stage of atherosclerosis only. However, calcification is currently considered as highly regulated and potentially reversible process.

Matrix Gla protein (MGP) represents natural inhibitor of vascular calcification, whereas vitamin K is key co-factor of its maturation to the active form. There is accumulating evidence that vitamin K status and corresponding MGP activity may influence cardiovascular risk. This review summarizes pathophysiological mechanism and recent evidence relative to MGP. Moreover, available data concerning vitamin K supplementation are depicted.

Keywords:
matrix Gla protein, vitamin K, vascular calcifications, cardiovascular diseases

Zdroje

1. Yusuf S, Hawken S, Ounpuu S et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004; 364: 937–952.

2. Greenland P et al. ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography). Circulation 2007; 115: 402–426.

3. Pletcher MJ, Tice JA, Pignone M, Browner WS. Using the coronary artery calcium score to predict coronary heart disease events: a systematic review and meta-analysis. Arch Intern Med 2004; 164: 1285–1292.

4. Rumberger JA, Simons DB, Fitzpatrick LA et al. Coronary artery calcium area by electron-beam computed tomography and coronary atherosclerotic plaque area. A histopathologic correlative study. Circulation 1995; 92: 2157–2162.

5. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation 1995; 92: 657–671.

6. Demer LL, Tintut Y. The leading edge of vascular calcification. Trends Cardiovasc Med 2015; 25: 275–277.

7. Price PA, Urist MR, Otawara Y. Matrix Gla protein, a new gamma-carboxyglutamic acid-containing protein which is associated with the organic matrix of bone. Biochem Biophys Res Commun 1983; 117: 765–771.

8. Shanahan CM, Proudfoot D, Farzaneh-Far A, Weissberg PL. The role of Gla proteins in vascular calcification. Crit Rev Eukaryot Gene Expr 1998; 8: 357–375.

9. Luo G, Ducy P, McKee MD et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix Gla protein. Nature 1997; 386: 78–81.

10. Schurgers LJ, Cranenburg EC, Vermeer C. Matrix Gla-protein: the calcification inhibitor in need of vitamin k. Thromb Haemost 2008; 100: 593–603.

11. Kruger T, Oelenberg S, Kaesler N et al. Warfarin induces cardiovascular damage in mice. Arterioscler Thromb Vasc Biol 2013; 33: 2618–2624.

12. Cranenburg EC, Koos R, Schurgers LJ et al. Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb Haemost 2010; 104: 811–822.

13. Schurgers LJ, Spronk HM, Skepper JN et al. Post-translational modifications regulate matrix Gla protein function: Importance for inhibition of vascular smooth muscle cell calcification. J Thromb Haemost 2007; 5: 2503–2511.

14. Cranenburg EC, Brandenburg VM, Vermeer C et al. Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients. Thromb Haemost 2009; 101: 359–366.

15. Mayer O jr., Seidlerová J, Vaněk J et al. The abnormal status of uncarboxylated matrix Gla protein species represents an additional mortality risk in heart failure patients with vascular disease. Int J Cardiol 2016; 203: 916–922.

16. Mayer O jr., Seidlerová J, Wohlfahrt P et al. Desphospho-uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population. J Hum Hypertens 2016 Jul; 30(7): 418–423.

17. Theuwissen E, Smit E, Vermeer C. The role of vitamin K in soft-tissue calcification. Adv Nutr 2012; 3: 166–173.

18. Dalmeijer GW, van der Schouw YT, Vermeer C et al. Circulating matrix Gla protein is associated with coronary artery calcification and vitamin K status in healthy women. J Nutr Biochem 2013; 24: 624–628.

19. van den Heuvel EG, van Schoor NM, Lips P et al. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease. Maturitas 2014; 77: 137–141.

20. Schurgers LJ, Barreto DV, Barreto FC et al. The circulating inactive form of matrix Gla protein is a surrogate marker for vascular calcification in chronic kidney disease: A preliminary report. Clin J Am Soc Nephrol 2010; 5: 568–575.

21. Ueland T, Gullestad L, Dahl CP et al. Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis. J Intern Med 2010; 268: 483–492.

22. Ueland T, Dahl CP, Gullestad L et al. Circulating levels of non-phosphorylated undercarboxylated matrix gla protein are associated with disease severity in patients with chronic heart failure. Clin Sci (Lond) 2011; 121: 119–127.

23. Mustonen E, Pohjolainen V, Aro J et al. Upregulation of cardiac matrix Gla protein expression in response to hypertrophic stimuli. Blood Press 2009; 18: 286–293.

24. Bostrom K, Zebboudj AF, Yao Y et al. Matrix Gla protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells. J Biol Chem 2004; 279: 52904–52913.

25. Yao Y, Zebboudj AF, Shao E et al. Regulation of bone morphogenetic protein-4 by matrix Gla protein in vascular endothelial cells involves activin-like kinase receptor 1. J Biol Chem 2006; 281: 33921–33930.

26. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: A systematic review and meta-analysis. J Am Coll Cardiol 2010; 55: 1318–1327.

27. Pivin E, Ponte B, Pruijm M et al. Inactive matrix Gla-protein is associated with arterial stiffness in an adult population-based study. Hypertension 2015; 66: 85–92.

28. Gast GC, de Roos NM, Sluijs I et al. A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metab Cardiovasc Dis 2009; 19: 504–510.

29. Geleijnse JM, Vermeer C, Grobbee DE et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The rotterdam study. J Nutr 2004; 134: 3100–3105.

30. Beulens JW, Bots ML, Atsma F et al. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis 2009; 203: 489–493.

31. Schurgers LJ, Spronk HM, Soute BA et al. Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats. Blood 2007; 109: 2823–2831.

32. Braam LA, Hoeks AP, Brouns F et al. Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Thromb Haemost 2004; 91: 373–380.

33. Shea MK, O'Donnell CJ, Hoffmann U et al. Vitamin K supplementation and progression of coronary artery calcium in older men and women. Am J Clin Nutr 2009; 89: 1799–1807.

34. Knapen MH, Braam LA, Drummen NE et al. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost 2015; 113: 1135–1144.

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