Role of blood biomarkers in spontaneous intracerebral hemorrhage – a prospectively studied cohort of patients

Česká verzia

Authors: Jolana Mračková ¹; Tereza Růžičková ²; Petr Ševčík ¹; Marie Karlíková ³; Jan Mraček ⁴; Jiří Polívka ¹
Authors place of work: Neurologická klinika LF UK a FN Plzeň ¹; Neurologická klinika 2. LF UK a FN Motol, Praha ²; Oddělení imunochemické diagnostiky FN Plzeň ³; Neurochirurgická klinika LF UK a FN Plzeň ⁴
Published in the journal: Čas. Lék. čes. 2020; 159: 185-191
Category: Original Articles

Summary

The study of blood biomarkers can offer new possibilities in diagnostics, prognostication, determination of etiology, and management of spontaneous intracerebral hemorrhage. The aim of our study was to assess the relationship between a panel of selected blood biomarkers and clinical and radiodiagnostic parameters in patients with spontaneous intracerebral hemorrhage. Primarily, the aim was to find a prognostic biomarker which could help in deciding on the optimal categorization of treatment. A total of 70 patients were prospectively included in this study.

As shown by our findings, higher levels of S100B protein are associated with larger hematoma volume. They predict hematoma progression and an unfavorable outcome. One other positive correlation was found between hematoma volume and interleukin 6, interleukin 10 and blood glucose. Lower levels of matrix metalloproteinase 9 are an independent prognostic factor for hematoma progression in patients with spontaneous intracerebral hemorrhage.

Keywords:

blood biomarkers – spontaneous intracerebral hemorrhage – prognostication – hematoma volume

Zdroje

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Štítky

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

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