Perioperative management of metformin: is there something new?

Česká verzia

Authors: Alena Linhartová ¹; Irena Murínová ^2,3; Michaela Kovačič ²; Jana Gregorová ^3,4
Authors place of work: oddělení klinické farmacie Thomayerovy nemocnice, Praha ¹; oddělení klinické farmacie ÚVN – VoFN Praha ²; Ústav aplikované farmacie FaF MU, Brno ³; oddělení klinické farmacie Nemocnice Na Bulovce, Praha ⁴
Published in the journal: Čas. Lék. čes. 2020; 159: 210-212
Category: Review Article

Summary

Metformin is the drug of choice in the treatment of type 2 diabetes mellitus. Diabetic patients treated with metformin, who are scheduled for surgery, have always been subjects to discussion regarding the perioperative management of metformin because of the risk of developing lactic acidosis. The article presents the basic informations about this adverse event, describes new approach to the metformin treatment in the perioperative period, and summarizes the recommendations of professional societies and expert groups.

Keywords:

metformin – perioperative medication management – lactic acidosis

Zdroje

Škrha J, Pelikánová T, Prázný M et al. Doporučený́ postup péče o diabetes mellitus 2. typu. Česká diabetologická společnost ČLS JEP, 31. 5. 2020. Dostupné na: www.diab.cz/dokumenty/Standardy_DM.pdf
Svačina Š. Diabetologie. Triton, Praha, 2010.
SÚKL. Databáze léků. Dostupné na: www.sukl.cz
Lalau J, Kajbaf F, Protti A et al. Metformin-associated lactic acidosis (MALA): moving towards a new paradigm. Diabetes Obes Metab 2017; 19: 1502–1512.
Svačina Š. Laktátová acidóza. Medicabaze.cz: Lékařské repetitorium online. Dostupné na: www.medicabaze.cz
Salpeter S, Greyber E, Pasternak G et al. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2010; 4: CD002967.
Lalau J, Lacroix C, Compagnon P et al. Role of metformin accumulation in metformin-associated lactic acidosis. Diabetes Care 1995; 18: 779–784.
Lalau J, Race J. Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations. Drug Saf 1999; 20: 377–384.
Stades A, Heikens J, Erkelens D et al. Metformin and lactic acidosis: cause or coincidence? A review of case reports. J Intern Med 2004; 255: 179–187.
Duong J, Furlong T, Roberts D et al. The role of metformin in metformin-associated lactic acidosis (MALA): Case series and formulation of a model of pathogenesis. Drug Saf 2013; 36: 733–746.
Kajbaf F, Lalau J. The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis. BMC Pharmacol Toxicol 2013; 14: 22.
Seidowsky A, Nseir S, Houdret N et al. Metformin-associated lactic acidosis: a prognostic and therapeutic study. Crit Care Med 2009; 37: 2191–2196.
Yeung C, Chung H, Fong B et al. Metformin-associated lactic acidosis in Chinese patients with type II diabetes. Pharmacology 2011; 88: 260–265.
Rena G, Hardie D, Pearson E. The mechanisms of action of metformin. Diabetologia 2017; 60: 1577–1585.
Graham G, Punt J, Arora M et al. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 2011; 50: 81–98.
Kajbaf F, De Broe M, Lalau J. Therapeutic concentrations of metformin: a systematic review. Clin Pharmacokinet 2016; 55: 439–459.
Vecchio S, Giampreti A, Petrolini V et al. Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy. Clin Toxicol 2014; 52: 129–135.
Lalau J, Azzoug M, Kajbaf F et al. Metformin accumulation without hyperlactataemia and metformin-induced hyperlactataemia without metformin accumulation. Diabetes Metab 2014; 40: 220–223.
Odborné stanovisko České diabetologické společnosti k podávání metforminu v perioperačním období. Česká diabetologická společnost ČLS JEP, 31. 1. 2020. Dostupné na: www.diab.cz/dokumenty/Lecba_metfominem.pdf
Karen I, Svačina Š, Jurašková B. Diabetes mellitus, léčba u starších pacientů v ČR. Novelizace 2019. Doporučené diagnostické a terapeutické postupy pro všeobecné praktické lékaře. Společnost všeobecného lékařství ČLS JEP, 2019. Dostupné na: www.svl.cz/files/files/Doporucene-postupy/2017/DM-u-starsich-pac-2019.pdf
Khan N, Ghali W, Cagliero E. Perioperative management of blood glucose in adults with diabetes mellitus. UpToDate 2018.
Cosson E, Catargi B, Cheisson G et al. Practical management of diabetes patients before, during and after surgery: a joint French diabetology and anaesthesiology position statement. Diabetes Metab 2018; 44: 200–216.
American Diabetes Association. 15. diabetes care in the hospital: Standards of medical care in diabetes – 2019. Diabetes Care. Diabetes Care 2019; 42: S173–S181.
Barker P, Creasey PE, Dhatariya K et al. Peri‐operative management of the surgical patient with diabetes 2015: Association of Anaesthetists of Great Britain and Ireland. Anaesthesia 2015; 70: 1427–1440.
Dhatariya K, Levy N, Kilvert A et al. NHS Diabetes guideline for the perioperative management of the adult patient with diabetes. Diabetic Medicine 2012; 29: 420–33.
Peri-operative Diabetes Management Guidelines. Australian Diabetes Society, 2012 Jul. Dostupné na: https://diabetessociety.com.au/documents/PerioperativeDiabetesManagementGuidelinesFINALCleanJuly2012.pdf

Štítky

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Článek Úvodem

Článek The role of the vascular surgery in oncosurgery

Článek Obstacles and problems in global elimination of viral hepatitis C

Článek Exploratory drilling: how to set up, carry out, and evaluate a seroprevalence study

Článek Memorandum Johna Snowa: Vědecký konsensus k pandemii COVID-19. Je potřeba jednat

Článek Opinions and attitudes of experts to the digitization of the Czech healthcare: preliminary report on the implementation of the first wave of the DELPHI study

Článek Hydroterapie v díle Aula Cornelia Celsa

Článek Veřejné wittenberské pitvy Jana Jessenia

Článek Josef Jan Čejka, Božena Němcová a George Sandová

Článek James Whyte Black (1924–2010)

Článek Dva v jednom: Polytrauma a komplikace v chirurgické péči + Dopravní úrazy

Článek Moje vzpomínky na prof. Jiřího Widimského st.