Perspective of pancreatic ductal adenocarcinoma imaging with 68Ga neurotensin analogues

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Authors: Marina Hodolič ^1,3; Feng Wang ²; Wenyu Wu ²; Pavel Koranda ³
Authors place of work: Nuclear Medicine Research Department IASON, Graz, Austria, 2 Department of Nuclear Medicine, Nanjing First, Hospital, Nanjing, Medical University, Nanjing, China, 3 Klinika nukleární medicíny, LF UP Olomouc, ČR ¹
Published in the journal: NuklMed 2021;10:63-67
Category: Review Article

Summary

Cells of pancreatic ductal adenocarcinoma (PDAC) express neurotensin receptors. Preclinical trials have successfully shown that neurotensin analogues have the potential for PET imaging of PDAC. Based on the published data, NTR-1 is promising target for the development of radioactive analogues for both imaging and therapy in patients with primary and metastatic pancreatic ductal adenocarcinoma. However, the first in vivo studies using ⁶⁸Ga DOTA-NT-20.3 in patients did not image PDAC tumours in all cases with very high contrast to surrounding tissue. Peptid research in the field of neurotensin analogues continues in an effort to further enhance the affinity of PET peptide radiopharmaceuticals for neurotensin receptors.

Keywords:

PET/CT – ancreatic cancer – neurotensin – in vivo human study

Zdroje

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