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preLekára.sk / Journals / Nuclear Medicine / 2023 - 1

Assessment of liver and its rezidual functional capacity after an extensive resection

Česká verzia

Authors: M. Havel 1,2;  A. Vašura 3;  V. Dedek 1,2;  P. Širůček 1,2;  O. Kraft 1,2;  G. Havlová 1;  P. Vávra 4;  M. Vávrová 5;  S. Bobková 1;  K. Trulíková 1
Authors place of work: Klinika nukleární medicíny, Fakultní nemocnice Ostrava 1;  Katedra zobrazovacích metod, Lékařská fakulta Ostravské univerzity 2;  Interní a kardiologická klinika, Fakultní nemocnice Ostrava 3;  Chirurgická klinika, Fakultní nemocnice Ostrava a Lékařská fakulta Ostravské univerzity 4;  Radiodiagnostický ústav, Fakultní nemocnice Ostrava, ČR 5
Published in the journal: NuklMed 2023;12:2-8
Category: Review Article

Summary

Introduction: Extensive resections in liver parenchyma can lead to the liver dysfunction or liver failure due to the insufficient postoperative remnant. Indication process involves direct and indirect methods for the assessment of liver function.

Topic solved: Morphological imaging methods estimate the liver remnant function mainly based on the volume calculations. Laboratory tests asses rather global function and they may not always correlate with the patient’s prognosis. Scintigraphic methods include monitoring of accumulation of iminodiacetic acid derivatives (IDA), especially determination of hepatic extraction fraction (HEF) and calculation of IDA uptake rate in liver parenchyma.

Conclusion: Scintigraphic methods can be used for the estimation of the liver remnant function during the indication for the extensive liver resections. Especially the calculation of IDA uptake rate in liver parenchyma is potent to identify patients in a higher risk of future liver failure.

Keywords:

function – resection – scintigraphy – liver – IDA

Zdroje
  1. Van Den Broek MAJ, Olde Damink SWM, Dejong CHC, et al. Liver failure after partial hepatic resection: definition, pathophysiology, risk factors and treatment. Liver Int. 2008;28:767-780
  2. de Santibañes E, Alvarez FA, Ardiles V. How to Avoid Postoperative Liver Failure: A Novel Method. World J Surg. 2012;36:125-128
  3. Olthof PB, Tomassini F, Huespe PE, et al. Hepatobiliary scintigraphy to evaluate liver function in associating liver partition and portal vein ligation for staged hepatectomy: Liver volume overestimates liver function. Surgery. 2017;162:775-783
  4. Bozic D, Podrug K, Mikolasevic I, et al. Ultrasound Methods for the Assessment of Liver Steatosis: A Critical Appraisal. Diagnostics. 2022;12:2287
  5. Gasperi A De, Mazza E, Prosperi M. Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery? World J Hepatol. 2016;8:355
  6. Guerra Ruiz AR, Crespo J, López Martínez RM, et al. Measurement and clinical usefulness of bilirubin in liver disease. Adv Lab Med/Av en Med Lab. 2021;2:352-361
  7. Šmíd V. Liver fibrosis. Vnitr Lek. 2020;66:61-66
  8. Rassam F, Olthof PB, Bennink RJ, et al. Current Modalities for the Assessment of Future Remnant Liver Function. Visc Med. 2017;33:442-448
  9. Lichtinghagen R, Pietsch D, Bantel H, et al. The Enhanced Liver Fibrosis (ELF) score: Normal values, influence factors and proposed cut-off values. J Hepatol. 2013;59:236-242
  10. Faybik P, Hetz H. Plasma Disappearance Rate of Indocyanine Green in Liver Dysfunction. Transplant Proc. 2006;38:801-802
  11. Hines RL, Jones SB. Stoelting’s Anesthesia and Co-Existing Disease E-Book. Elsevier Health Sciences; 2021
  12. Moraes ACO de, Oliveira PC de, Fonseca-Neto OCL da. The impact of the meld score on liver transplant allocation and results: an integrative review. ABCD Arq Bras Cir Dig (São Paulo). 2017; 30:65-68
  13. Chan Y, Luk W, Cheng L, et al. Tc-99m sulfur colloid SPECT-CT and assessment of functional liver reserve after Y90 radioembolization: A case report. Int J Surg Case Rep. 2019;62:89-93
  14. Bowen SR, Chapman TR, Borgman J, et al. Measuring total liver function on sulfur colloid SPECT/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients. EJNMMI Res. 2016;6:57
  15. Zuckerman E, Slobodin G, Sabo E, et al. Quantitative liver-spleen scan using single photon emission computerized tomography (SPECT) for assessment of hepatic function in cirrhotic patients. J Hepatol. 2003;39:326-332
  16. Suzuki Y, Kakisaka K, Sato T, et al. Tc-99m GSA scintigraphy within the first 3 days after admission as an early predictor of outcome in severe acute liver injury. Sci Rep. 2021;11:12518
  17. Bennink RJ, Dinant S, Erdogan D, et al. Preoperative assessment of postoperative remnant liver function using hepatobiliary scintigraphy. J Nucl Med. 2004;45:965-971
  18. Howman-Giles R, Moase A, Gaskin K, et al. Hepatobiliary scintigraphy in a pediatric population: determination of hepatic extraction fraction by deconvolution analysis. J Nucl Med. 1993;34: 214-221
  19. Lieberman DA, Brown PH, Krishnamurthy GT. Improved scintigraphic assessment of severe cholestasis with the hepatic extraction fraction. Dig Dis Sci. 1990;35:1385-1390
  20. Brown PH, Juni JE, Lieberman DA, et al. Hepatocyte versus biliary disease: a distinction by deconvolutional analysis of technetium-99m IDA time-activity curves. J Nucl Med. 1988;29:623-630
  21. Prášek J. Atlas Dynamické Cholescintigrafie. 1. vyd. Praha: Agentura Pankrác; 2004, 72 p
  22. Ekman M, Fjälling M, Friman S, et al. Liver uptake function measured by IODIDA clearance rate in liver transplant patients and healthy volunteers. Nucl Med Commun. 1996;17:235-242
  23. de Graaf W, van Lienden KP, Dinant S, et al. Assessment of future remnant liver function using hepatobiliary scintigraphy in patients undergoing major liver resection. J Gastrointest Surg. 2010;14:369-378
  24. Llovet JM, Kelley RK, Villanueva A, et al. Hepatocellular carcinoma. Nat Rev Dis Prim. 2021;7:6
  25. Tomášek J, Tuček Š, Andrašina T. Hepatocelulární karcinom–diagnostika a terapie z pohledu klinického onkologa. Gastroenterol a Hepatol Gastroenterol a Hepatol. 2011;3:149-153 [online] [cit. 2022-12-10]. Dostupné na: https://www.prolekare.cz/casopisy/ceska-slovenska-gastro/2011-3-5/hepatocelularni-karcinom-diagnostika-a-terapie-z-pohledu-klinickeho-onkologa-35372
  26. Reig M, Forner A, Rimola J, et al. BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update. J Hepatol. 2022;76:681-693
  27. Martin J, Petrillo A, Smyth EC, et al. Colorectal liver metastases: Current management and future perspectives. World J Clin Oncol. 2020;11:761-808
  28. Rocha FG, Helton WS. Resectability of colorectal liver metastases: an evolving definition. HPB (Oxford). 2012;14:283-284
  29. Robinson SM, Wilson CH, Burt AD, et al. Chemotherapy-associated liver injury in patients with colorectal liver metastases: a systematic review and meta-analysis. Ann Surg Oncol. 2012;19:4287-4299
  30. Alvarez FA, Ardiles V, de Santibañes E. The ALPPS Approach for the Management of Colorectal Carcinoma Liver Metastases. Curr Colorectal Cancer Rep. 2013;9:168-177
  31. Markowicz-Piasecka M, Dębski P, Mikiciuk-Olasik E, et al. Synthesis and Biocompatibility Studies of New Iminodiacetic Acid Derivatives. Molecules. 2017;22:2265
  32. Chapelle T, Op de Beeck B, Roeyen G, et al. Measuring future liver remnant function prior to hepatectomy may guide the indication for portal vein occlusion and avoid posthepatectomy liver failure: a prospective interventional study. HPB. 2017;19:108-117
  33. Serenari M, Bonatti C, Zanoni L, et al. The role of hepatobiliary scintigraphy combined with spect/ct in predicting severity of liver failure before major hepatectomy: a single-center pilot study. Updates Surg. 2021;73:197-208
  34. Wang H, Feng M, Frey KA, et al. Predictive models for regional hepatic function based on 99mTc-IDA SPECT and local radiation dose for physiologic adaptive radiation therapy. Int J Radiat Oncol Biol Phys. 2013;86:1000-1006
  35. Wang H, Cao Y. Spatially resolved assessment of hepatic function using 99mTc-IDA SPECT. Med Phys. 2013;40:092501
  36. Nilsson H, Nordell A, Vargas R, et al. Assessment of hepatic extraction fraction and input relative blood flow using dynamic hepatocyte-specific contrast-enhanced MRI. J Magn Reson Imaging. 2009;29:1323-1331
  37. Papastergiou V, Tsochatzis E, Burroughs AK. Non-invasive assessment of liver fibrosis. Ann Gastroenterol. 2012;25:218-231
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Nuclear medicine Radiodiagnostics Radiotherapy
Článek Editorial
Článek Review of the most interesting news and trends of the 35th EANM congress
Článek Nukleární medicína a MUDr. Ladislav Šabata České Budějovice
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Článek Historický kvíz
Článek Sonda do historie
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Nuclear Medicine

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2023 Číslo 1
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