Influence of industrial mineral fiber dusts on respiration toxicity parameters – time dependence
Authors:
Hurbánková Marta 1; Černá Silvia; Tátrai Erzsébet 3; Barančoková Magdaléna 1; Kažimírová Alena 1; Volkovová Katarína 1; Staruchová Marta 1; Hrašková Dominika 1; Marcišiaková Jana 2; Wimmerová Soňa 1; Moricová Štefánia 1
Authors place of work:
Slovenská zdravotnícka univerzita, Bratislava, FVZ Slovensko, doc. MUDr. Štefánia Moricová, PhD., MPH, mimoriadny profesor, dekanka Fakulty verejného zdravotníctva
1; Medicínsko-preventívna s. r. o., Hnúšťa, Slovensko
2; National Institute of Environmental Health, Budapešť, Maďarsko
3
Published in the journal:
Pracov. Lék., 65, 2013, No. 3-4, s. 105-112.
Category:
Original Papers
Summary
The objective of the experimental investigation was to determine lung damage – respiratory toxicity – after exposure to selected industrial fiber dusts (glass fibers – GF, ceramic fibers – CF and amosite asbestos– AV as positive control) from the standpoint of time dependence. Animals were instilled with 4 mg glass fibers in 0,4 ml saline solution/animal, the control group with 0,4 ml saline solution. Wistar rats were sacrificed and bronchoalveolar lavage (BAL) were performed after instillation – 2, 30, 90 days. The authors examined selected inflammation, cytotoxic, immunotoxic, clastogenic, genotoxic parameters, the antioxidant state parameters and lung histology [number of BAL cells and alveolar macrophages (AM); differential picture of BAL cells (% AM, polymorphonuclear cells and lymphocytes), % of immature AM cells, multinuclear cells, viability and phygocytic activity of AM cells, frequency of micronuclei (MN), comet assay, FRA (ferric reducing ability) and histology of the lung tissue]. The influence of the industrial dusts under observation on the changes of lung tissue decreased in the following order: AMO > KV > SV. The course of time dependence curves of BAL parameters after exposure to all industrial fibers under investigation proved to be very similar. The explanation of their different consequences (finally the origin of disease) may be in their different biopersistence.
Keywords:
respiration toxicity – asbestos, ceramic and glass fibers – inflammation, cytotoxic, immunotoxic, clastogenic, genotoxic parameters of antioxidant state and lung histology – bronchoalveolar lavage
Zdroje
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Štítky
Hygiene and epidemiology Hyperbaric medicine Occupational medicineČlánok vyšiel v časopise
Occupational Medicine
2013 Číslo 3-4
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